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    Plcg2 phospholipase C, gamma 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29337, updated on 23-Dec-2018

    Summary

    Official Symbol
    Plcg2provided by RGD
    Official Full Name
    phospholipase C, gamma 2provided by RGD
    Primary source
    RGD:3348
    See related
    Ensembl:ENSRNOG00000051986
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    has phosphoinositide-specific phospholipase C activity [RGD, Feb 2006]
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Biased expression in Spleen (RPKM 196.8), Thymus (RPKM 52.5) and 5 other tissues See more
    Orthologs

    Genomic context

    See Plcg2 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (50039410..50173543)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (60828451..60962641)

    Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene c-Maf-inducing protein Neighboring gene ATP synthase subunit f, mitochondrial-like Neighboring gene uncharacterized LOC102548350 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    activation of store-operated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of store-operated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    follicular B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    follicular B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    inositol trisphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inositol trisphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    inositol trisphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of type I interferon production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    release of sequestered calcium ion into cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to ATP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    response to magnesium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    Names
    PLC-IV
    PLC-gamma-2
    phosphoinositide phospholipase C
    phosphoinositide phospholipase C-gamma-2
    phospholipase C-IV
    NP_058864.1
    XP_017456737.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017168.1NP_058864.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

      See identical proteins and their annotated locations for NP_058864.1

      Status: PROVISIONAL

      Source sequence(s)
      J05155
      UniProtKB/Swiss-Prot
      P24135
      Related
      ENSRNOP00000069801.1, ENSRNOT00000090165.1
      Conserved Domains (9) summary
      cd00275
      Location:10611187
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08592
      Location:311458
      PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
      cd09932
      Location:641744
      SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
      cd10341
      Location:527627
      SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
      cd11969
      Location:773827
      SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
      cd13234
      Location:840910
      PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
      cd13362
      Location:22140
      PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
      cl14615
      Location:9261031
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl17171
      Location:475510
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

      Range
      50039410..50173543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601248.1XP_017456737.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1

    Alternate Rn_Celera

    Genomic

    1. AC_000087.1 Alternate Rn_Celera

      Range
      44819007..44954904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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