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    PARP1 poly(ADP-ribose) polymerase 1 [ Bos taurus (cattle) ]

    Gene ID: 286764, updated on 20-Jan-2019

    Summary

    Gene symbol
    PARP1
    Gene description
    poly(ADP-ribose) polymerase 1
    See related
    BGD:BT27335; Ensembl:ENSBTAG00000000837
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ADPRT; ARTD1
    Orthologs

    Genomic context

    See PARP1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 16 NC_037343.1 (29365008..29406457, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 16 AC_000173.1 (30119195..30160574, complement)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene lin-9 DREAM MuvB core complex component Neighboring gene trithorax group protein osa-like Neighboring gene isopentenyl-diphosphate Delta-isomerase 1-like Neighboring gene uncharacterized LOC112441786 Neighboring gene stum, mechanosensory transduction mediator homolog

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein ADP-ribosylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ATP generation from poly-ADP-D-ribose ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA ADP-ribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to DNA damage stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    double-strand break repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-glutamic acid poly-ADP-ribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-serine ADP-ribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cardiac muscle hypertrophy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein ADP-ribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein auto-ADP-ribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein poly-ADP-ribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    site of DNA damage ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    poly [ADP-ribose] polymerase 1
    Names
    ADP-ribosyltransferase (NAD+) poly (ADP-ribose) polymerase)
    ADP-ribosyltransferase diphtheria toxin-like 1
    ADPRT 1
    DNA ADP-ribosyltransferase PARP1
    NAD(+) ADP-ribosyltransferase 1
    PARP-1
    poly (ADP-ribose) polymerase family, member 1
    poly(ADP-ribose) synthetase
    poly[ADP-ribose] synthase 1
    poly[ADP-ribose] synthetase 1
    protein poly-ADP-ribosyltransferase PARP1
    NP_777176.1
    XP_005216853.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174751.2NP_777176.1  poly [ADP-ribose] polymerase 1

      See identical proteins and their annotated locations for NP_777176.1

      Status: PROVISIONAL

      Source sequence(s)
      D90073
      UniProtKB/Swiss-Prot
      P18493
      Related
      ENSBTAP00000001113.4, ENSBTAT00000001113.5
      Conserved Domains (6) summary
      cd08001
      Location:545647
      WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
      PLN03123
      Location:61012
      PLN03123; poly [ADP-ribose] polymerase; Provisional
      cd01437
      Location:6641008
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00533
      Location:387463
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00645
      Location:1287
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam08063
      Location:283334
      PADR1; PADR1 (NUC008) domain

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      29365008..29406457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005216796.4XP_005216853.1  poly [ADP-ribose] polymerase 1 isoform X1

      Conserved Domains (6) summary
      cd08001
      Location:542644
      WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
      PLN03123
      Location:61009
      PLN03123; poly [ADP-ribose] polymerase; Provisional
      cd01437
      Location:6611005
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00533
      Location:384460
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00645
      Location:1287
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam08063
      Location:280331
      PADR1; PADR1 (NUC008) domain
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