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    MMP14 matrix metallopeptidase 14 [ Bos taurus (cattle) ]

    Gene ID: 281915, updated on 12-May-2019

    Summary

    Official Symbol
    MMP14provided by VGNC
    Official Full Name
    matrix metallopeptidase 14provided by VGNC
    Primary source
    VGNC:VGNC:31519
    See related
    BGD:BT22119; Ensembl:ENSBTAG00000014824
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See MMP14 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 10 NC_037337.1 (21969250..21977729, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 10 AC_000167.1 (21806054..21814533, complement)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 23 Neighboring gene RRAD and GEM like GTPase 2 Neighboring gene LDL receptor related protein 10 Neighboring gene mitochondrial ribosomal protein L52 Neighboring gene uncharacterized LOC112448396 Neighboring gene solute carrier family 7 member 7

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    branching morphogenesis of an epithelial tube ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lung development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of myotube differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    zymogen activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    melanosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    matrix metalloproteinase-14
    Names
    MMP-14
    MT-MMP 1
    MT1-MMP
    MT1MMP
    MTMMP1
    matrix metallopeptidase 14 (membrane-inserted)
    matrix metalloproteinase 14 (membrane-inserted)
    matrix metalloproteinase 14 preproprotein
    membrane-type matrix metalloproteinase 1
    membrane-type-1 matrix metalloproteinase
    NP_776815.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174390.2NP_776815.1  matrix metalloproteinase-14 precursor

      See identical proteins and their annotated locations for NP_776815.1

      Status: PROVISIONAL

      Source sequence(s)
      AF290429
      UniProtKB/Swiss-Prot
      Q9GLE4
      Related
      ENSBTAP00000019744.5, ENSBTAT00000019744.5
      Conserved Domains (5) summary
      cd00094
      Location:315507
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:117283
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:117283
      Peptidase_M10; Matrixin
      pfam01471
      Location:3587
      PG_binding_1; Putative peptidoglycan binding domain
      pfam11857
      Location:560582
      DUF3377; Domain of unknown function (DUF3377)

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      21969250..21977729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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