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    FGF2 fibroblast growth factor 2 [ Bos taurus (cattle) ]

    Gene ID: 281161, updated on 14-Jan-2019

    Summary

    Gene symbol
    FGF2
    Gene description
    fibroblast growth factor 2
    See related
    BGD:BT10549; Ensembl:ENSBTAG00000005691
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    BFGF; FGF-2; HBGF-2
    Orthologs

    Genomic context

    See FGF2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 17 NC_037344.1 (34801330..34860849, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 17 AC_000174.1 (35199615..35259135, complement)

    Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 5 Neighboring gene small nucleolar RNA SNORA11 Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 2 pseudogene Neighboring gene nudix hydrolase 6 Neighboring gene Bardet-Biedl syndrome 12 Neighboring gene centrin 4

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    fibroblast growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    activation of MAPKK activity IEA
    Inferred from Electronic Annotation
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    branching involved in ureteric bud morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    corticotropin hormone secreting cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    glial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    lung development IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell death ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    organ induction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of blood vessel endothelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration involved in sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cerebellar granule cell precursor proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of retinal cell programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to axon injury IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    stem cell development IEA
    Inferred from Electronic Annotation
    more info
     
    substantia nigra development IEA
    Inferred from Electronic Annotation
    more info
     
    thyroid-stimulating hormone-secreting cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    fibroblast growth factor 2
    Names
    basic fibroblast growth factor
    fibroblast growth factor 2 (basic)
    heparin-binding growth factor 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174056.4NP_776481.2  fibroblast growth factor 2 precursor

      Status: VALIDATED

      Source sequence(s)
      DAAA02044761
      UniProtKB/TrEMBL
      F1N3T9
      Related
      ENSBTAP00000007477.5, ENSBTAT00000007477.5
      Conserved Domains (1) summary
      pfam00167
      Location:28149
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037344.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      34801330..34860849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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