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    Slamf1 signaling lymphocytic activation molecule family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 27218, updated on 31-Jan-2019

    Summary

    Official Symbol
    Slamf1provided by MGI
    Official Full Name
    signaling lymphocytic activation molecule family member 1provided by MGI
    Primary source
    MGI:MGI:1351314
    See related
    Ensembl:ENSMUSG00000015316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Slam; CD150; IPO-3; CDw150; ESTM51; AA177906; 4933415F16
    Expression
    Biased expression in thymus adult (RPKM 5.3), spleen adult (RPKM 1.6) and 5 other tissues See more
    Orthologs

    Genomic context

    See Slamf1 in Genome Data Viewer
    Location:
    1 H3; 1 79.54 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (171767132..171801184)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (173697263..173731315)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene CD48 antigen Neighboring gene adaptor-related protein complex 3, sigma 1 subunit pseudogene Neighboring gene CD84 antigen Neighboring gene predicted gene, 37065 Neighboring gene SLAM family member 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC151472, MGC151476

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    T-helper 1 cell cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    leukocyte chemotaxis involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymphocyte activation IEA
    Inferred from Electronic Annotation
    more info
     
    myeloid dendritic cell activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    natural killer cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    natural killer cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of CD40 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of T cell cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interferon-gamma secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of activated T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of dendritic cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-gamma secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of macrophage chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of catalytic activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    signaling lymphocytic activation molecule
    Names
    SLAM family member 1
    signaling lymphocyte activation molecule

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360898.1NP_001347827.1  signaling lymphocytic activation molecule isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC091521, AK037780
      Conserved Domains (2) summary
      pfam06214
      Location:1126
      SLAM; Signaling lymphocytic activation molecule (SLAM) protein
      pfam13927
      Location:144216
      Ig_3; Immunoglobulin domain
    2. NM_013730.4NP_038758.2  signaling lymphocytic activation molecule isoform 1 precursor

      See identical proteins and their annotated locations for NP_038758.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC091521
      Consensus CDS
      CCDS15502.1
      UniProtKB/Swiss-Prot
      Q9QUM4
      UniProtKB/TrEMBL
      Q544K1
      Related
      ENSMUSP00000015460.4, ENSMUST00000015460.4
      Conserved Domains (3) summary
      smart00410
      Location:162228
      IG_like; Immunoglobulin like
      pfam06214
      Location:1126
      SLAM; Signaling lymphocytic activation molecule (SLAM) protein
      cl11960
      Location:162227
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      171767132..171801184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496872.3XP_006496935.1  signaling lymphocytic activation molecule isoform X1

      Conserved Domains (2) summary
      pfam06214
      Location:17117
      SLAM; Signaling lymphocytic activation molecule (SLAM) protein
      cl11960
      Location:153218
      Ig; Immunoglobulin domain
    2. XM_006496873.2XP_006496936.1  signaling lymphocytic activation molecule isoform X2

      Conserved Domains (2) summary
      smart00410
      Location:2288
      IG_like; Immunoglobulin like
      cl11960
      Location:2287
      Ig; Immunoglobulin domain
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