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    Homer3 homer scaffolding protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 26558, updated on 9-Apr-2019

    Summary

    Official Symbol
    Homer3provided by MGI
    Official Full Name
    homer scaffolding protein 3provided by MGI
    Primary source
    MGI:MGI:1347359
    See related
    Ensembl:ENSMUSG00000003573
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW146114
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 62.8), ovary adult (RPKM 38.6) and 27 other tissues See more
    Orthologs

    Genomic context

    See Homer3 in Genome Data Viewer
    Location:
    8; 8 B3.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (70282891..70294361)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (72806898..72818260)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 6 Neighboring gene SURP and G patch domain containing 2 Neighboring gene predicted gene, 38427 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 Neighboring gene coatomer protein complex, subunit epsilon Neighboring gene ceramide synthase 1 Neighboring gene growth differentiation factor 1 Neighboring gene UPF1 regulator of nonsense transcripts homolog (yeast)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G protein-coupled glutamate receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    basal part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    homer protein homolog 3
    Names
    homer homolog 3
    homer, neuronal immediate early gene, 3
    homer-3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146153.1NP_001139625.1  homer protein homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_001139625.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC158553, BU054773, CX208892
      Consensus CDS
      CCDS52569.1
      UniProtKB/Swiss-Prot
      Q99JP6
      Related
      ENSMUSP00000105751.2, ENSMUST00000110124.8
      Conserved Domains (1) summary
      cd01206
      Location:6114
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    2. NM_011984.2NP_036114.2  homer protein homolog 3 isoform 2

      See identical proteins and their annotated locations for NP_036114.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AC158553, BU054773, CX208892
      Consensus CDS
      CCDS22363.1
      UniProtKB/Swiss-Prot
      Q99JP6
      Related
      ENSMUSP00000117033.1, ENSMUST00000140212.7
      Conserved Domains (1) summary
      cd01206
      Location:6114
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      70282891..70294361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509681.2XP_006509744.1  homer protein homolog 3 isoform X2

      Conserved Domains (1) summary
      cl17171
      Location:56114
      PH-like; Pleckstrin homology-like domain
    2. XM_006509679.1XP_006509742.1  homer protein homolog 3 isoform X1

      See identical proteins and their annotated locations for XP_006509742.1

      Conserved Domains (1) summary
      cd01206
      Location:6114
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    3. XM_006509680.3XP_006509743.1  homer protein homolog 3 isoform X1

      See identical proteins and their annotated locations for XP_006509743.1

      Conserved Domains (1) summary
      cd01206
      Location:6114
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
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