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    KAT2A lysine acetyltransferase 2A [ Homo sapiens (human) ]

    Gene ID: 2648, updated on 15-Apr-2019

    Summary

    Official Symbol
    KAT2Aprovided by HGNC
    Official Full Name
    lysine acetyltransferase 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:4201
    See related
    Ensembl:ENSG00000108773 MIM:602301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCN5; hGCN5; GCN5L2; PCAF-b
    Summary
    KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
    Expression
    Ubiquitous expression in ovary (RPKM 41.6), adrenal (RPKM 30.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See KAT2A in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (42113111..42121409, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40265129..40273382, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chromosome 17 open reading frame 113 Neighboring gene DExH-box helicase 58 Neighboring gene heat shock protein family B (small) member 9 Neighboring gene RAB5C, member RAS oncogene family Neighboring gene uncharacterized LOC105371781

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 NL4-3 replication requires KAT2A as replication is inhibited when KAT2A is deleted through CRISPR/Cas9 genome editing PubMed
    Knockdown of K(lysine) acetyltransferase 2A (KAT2A; GCN5L2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The K19A, K41Q, and K51A mutations decrease HIV-1 Tat binding to hGCN5, whereas the K50Q and K50R mutations increase the binding PubMed
    tat hGCN5 enhances HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter PubMed
    tat HIV-1 Tat is acetylated by hGCN5 on lysine's 50 and 51 PubMed
    tat Binding of HIV-1 Tat to hGCN5 is mediated by amino acids 20-48 of Tat (includes cysteine rich, core, and minimal activation domains of Tat) and by amino acids 111-151 (histone acetyltransferase domain) and 389-476 (bromodomain) of hGCN5 PubMed
    tat HIV-1 Tat inhibits the histone acetyltransferase and transcriptional activation activities of hGCN5, an effect mediated by amino acids 86-101 of Tat PubMed
    tat HIV-1 Tat recruits hGCN5, as well as other known cellular acetyltransferases, to the HIV-1 LTR promoter, an effect involved in the acetylation of histones H3 and H4, and HIV-1 transcriptional activation PubMed
    integrase gag-pol HIV-1 IN binds to GCN5, which requires the C-terminal region (amino acids 244-288) of IN PubMed
    gag-pol GCN5 acetylates lysine's 258, 264, 266, and 273 of HIV-1 IN and stimulates the catalytic activity of IN PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • B-WICH complex positively regulates rRNA expression, organism-specific biosystem (from REACTOME)
      B-WICH complex positively regulates rRNA expression, organism-specific biosystemThe B-WICH complex is a large 3 Mdalton complex containing SMARCA5 (SNF2H), BAZ1B (WSTF), ERCC6 (CSB), MYO1C (Nuclear myosin 1c) (Cavellan et al. 2006, Percipalle et al. 2006, Vintermist et al. 2001,...
    • C-MYC pathway, organism-specific biosystem (from Pathway Interaction Database)
      C-MYC pathway, organism-specific biosystem
      C-MYC pathway
    • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
      Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
    • Chromatin organization, organism-specific biosystem (from REACTOME)
      Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
    • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystem (from REACTOME)
      Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystemWhen found in cis, HD and PEST domain mutations act synergistically, increasing NOTCH1 transcriptional activity up to ~40-fold, compared with up to ~10-fold and up to ~2-fold increase with HD mutatio...
    • Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystem (from REACTOME)
      Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystemAs NOTCH1 PEST domain is intracellular, NOTCH1 PEST domain mutants are expected to behave as the wild-type NOTCH1 with respect to ligand binding and proteolytic cleavage mediated activation of signal...
    • Deubiquitination, organism-specific biosystem (from REACTOME)
      Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
      Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
      E2F transcription factor network
    • Epigenetic regulation of gene expression, organism-specific biosystem (from REACTOME)
      Epigenetic regulation of gene expression, organism-specific biosystemEpigenetic processes regulate gene expression by modulating the frequency, rate, or extent of gene expression in a mitotically or meiotically heritable way that does not entail a change in the DNA se...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • HATs acetylate histones, organism-specific biosystem (from REACTOME)
      HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem (from REACTOME)
      NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystemNICD1 produced by activation of NOTCH1 in response to Delta and Jagged ligands (DLL/JAG) presented in trans, traffics to the nucleus where it acts as a transcription regulator. In the nucleus, NICD1 ...
    • Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Notch Signaling Pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Notch signaling pathway, organism-specific biosystem (from KEGG)
      Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Notch signaling pathway, conserved biosystem (from KEGG)
      Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Notch-HLH transcription pathway, organism-specific biosystem (from REACTOME)
      Notch-HLH transcription pathway, organism-specific biosystemTHE NOTCH-HLH TRANSCRIPTION PATHWAY: Notch signaling was first identified in Drosophila, where it has been studied in detail at the genetic, molecular, biochemical and cellular levels (reviewed in ...
    • Positive epigenetic regulation of rRNA expression, organism-specific biosystem (from REACTOME)
      Positive epigenetic regulation of rRNA expression, organism-specific biosystemTranscription of rRNA genes is controlled by epigenetic activation and repression (reviewed in Percipalle and Farrants 2006, McStay and Grummt 2008, Goodfellow and Zomerdijk 2012, Grummt and Langst 2...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Pre-NOTCH Expression and Processing, organism-specific biosystem (from REACTOME)
      Pre-NOTCH Expression and Processing, organism-specific biosystemIn humans and other mammals the NOTCH gene family has four members, NOTCH1, NOTCH2, NOTCH3 and NOTCH4, encoded on four different chromosomes. Their transcription is developmentally regulated and tiss...
    • Pre-NOTCH Transcription and Translation, organism-specific biosystem (from REACTOME)
      Pre-NOTCH Transcription and Translation, organism-specific biosystemIn humans, the NOTCH protein family has four members: NOTCH1, NOTCH2, NOTCH3 and NOTCH4. NOTCH1 protein was identified first, as the product of a chromosome 9 gene translocated in T-cell acute lympho...
    • RNA Polymerase I Promoter Clearance, organism-specific biosystem (from REACTOME)
      RNA Polymerase I Promoter Clearance, organism-specific biosystemPromoter clearance is one of the rate-limiting steps in Polymerase I transcription. This step is composed of three phases, promoter opening, transcription initiation and promoter escape.
    • RNA Polymerase I Transcription, organism-specific biosystem (from REACTOME)
      RNA Polymerase I Transcription, organism-specific biosystemThe rRNA genes are transcribed by RNA polymerase I, one of three eukaryotic nuclear RNA polymerases. The polymerase is a multisubunit complex, composed of two large subunits (the most conserved porti...
    • RNA Polymerase I Transcription Initiation, organism-specific biosystem (from REACTOME)
      RNA Polymerase I Transcription Initiation, organism-specific biosystemDuring initiation the double-stranded DNA must be melted and transcription begins. SL1 forms and interacts with UBF-1 and the rDNA promoter. It is this platform that will recruit active RNA polymeras...
    • RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, organism-specific biosystem (from REACTOME)
      RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, organism-specific biosystemTranscription by RNA Polymerase I, RNA Polymerase III and transcription from mitochondrial promoters.
    • Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
      Regulation of nuclear SMAD2/3 signaling
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
    • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...
    • Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystemMutations in the heterodimerization domain (HD) and PEST domain of NOTCH1 are frequently found in cis in T-cell acute lymphoblastic leukemia. While HD mutations alone result in up to ~10-fold increas...
    • Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystemNOTCH1 PEST domain mutations are frequently found in T-cell acute lymphoblastic leukemia (T-ALL). PEST domain mutations interfere with ubiquitination-mediated NOTCH1 downregulation and result in prol...
    • Signaling by NOTCH1 in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 in Cancer, organism-specific biosystemHuman NOTCH1 was cloned as a chromosome 9 gene, translocated to the T-cell beta receptor (TCBR) promoter on chromosome 7 in T-cell acute lymphoblastic leukemia (T-ALL) (Ellisen et al. 1991). This tra...
    • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
      Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
    • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
      Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...
    • Validated targets of C-MYC transcriptional activation, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional activation, organism-specific biosystem
      Validated targets of C-MYC transcriptional activation
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102791

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    H3 histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone acetyltransferase activity TAS
    Traceable Author Statement
    more info
     
    histone acetyltransferase activity (H4-K12 specific) IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone succinyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide-lysine-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    alpha-tubulin acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to nerve growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin remodeling TAS
    Traceable Author Statement
    more info
    PubMed 
    cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    histone H3 acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H3-K14 acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone H4-K12 acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone succinylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    internal peptidyl-lysine acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular distribution of mitochondria IEA
    Inferred from Electronic Annotation
    more info
     
    limb development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    long-term memory ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metencephalon development IEA
    Inferred from Electronic Annotation
    more info
     
    midbrain development IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of centriole replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cardiac muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression, epigenetic TAS
    Traceable Author Statement
    more info
     
    positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of histone acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    regulation of T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of regulatory T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
     
    response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    telencephalon development IEA
    Inferred from Electronic Annotation
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Ada2/Gcn5/Ada3 transcription activator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    STAGA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space HDA PubMed 
    mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with oxoglutarate dehydrogenase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor TFTC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone acetyltransferase KAT2A
    Names
    GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2
    General control of amino acid synthesis, yeast, homolog-like 2
    K(lysine) acetyltransferase 2A
    STAF97
    general control of amino acid synthesis protein 5-like 2
    histone acetyltransferase GCN5
    histone succinyltransferase KAT2A
    hsGCN5
    NP_066564.2
    XP_006721880.1
    XP_006721881.1
    XP_016879937.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021078.3NP_066564.2  histone acetyltransferase KAT2A

      See identical proteins and their annotated locations for NP_066564.2

      Status: VALIDATED

      Source sequence(s)
      AC105024, BC105977, DB497139
      Consensus CDS
      CCDS11417.1
      UniProtKB/Swiss-Prot
      Q92830
      Related
      ENSP00000225916.5, ENST00000225916.10
      Conserved Domains (4) summary
      cd05509
      Location:732831
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:492832
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00583
      Location:555627
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam06466
      Location:86335
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      42113111..42121409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006721818.4XP_006721881.1  histone acetyltransferase KAT2A isoform X2

      See identical proteins and their annotated locations for XP_006721881.1

      Conserved Domains (3) summary
      cd05509
      Location:372471
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:131472
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00583
      Location:194266
      Acetyltransf_1; Acetyltransferase (GNAT) family
    2. XM_006721817.4XP_006721880.1  histone acetyltransferase KAT2A isoform X1

      See identical proteins and their annotated locations for XP_006721880.1

      Conserved Domains (4) summary
      cd05509
      Location:733832
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:492833
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00583
      Location:555627
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam06466
      Location:86335
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
    3. XM_017024448.1XP_016879937.1  histone acetyltransferase KAT2A isoform X3

      UniProtKB/Swiss-Prot
      Q92830
      Conserved Domains (3) summary
      cd05509
      Location:371470
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:131471
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00583
      Location:194266
      Acetyltransf_1; Acetyltransferase (GNAT) family
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