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    Acp5 acid phosphatase 5, tartrate resistant [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25732, updated on 18-Apr-2019

    Summary

    Official Symbol
    Acp5provided by RGD
    Official Full Name
    acid phosphatase 5, tartrate resistantprovided by RGD
    Primary source
    RGD:2022
    See related
    Ensembl:ENSRNOG00000046261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Trap; TTRRAP
    Summary
    tartrate-resistant acid phosphatase; may be involved in bone resorption; 5b isoform is osteoclast-specific and may be a specific marker of bone resorption [RGD, Feb 2006]
    Expression
    Biased expression in Spleen (RPKM 417.2), Kidney (RPKM 210.0) and 4 other tissues See more
    Orthologs

    Genomic context

    See Acp5 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (23142733..23149067, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (23197095..23202903, complement)

    Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene calponin 1 Neighboring gene elongation factor 1 homolog Neighboring gene rCG31672-like Neighboring gene zinc finger protein 709-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acid phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    acid phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acid phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    ferric iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ferric iron binding IEA
    Inferred from Electronic Annotation
    more info
     
    ferric iron binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ferric iron binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ferrous iron binding IEA
    Inferred from Electronic Annotation
    more info
     
    ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ferrous iron binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    bone morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    bone morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    bone resorption IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    bone resorption IEA
    Inferred from Electronic Annotation
    more info
     
    bone resorption IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    bone resorption ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    bone resorption TAS
    Traceable Author Statement
    more info
    PubMed 
    defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    multicellular organismal response to stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of interleukin-1 beta production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ossification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ossification IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    osteoclast differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to L-ascorbic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to cholesterol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to cytokine IEA
    Inferred from Electronic Annotation
    more info
     
    response to cytokine ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lysosome TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    tartrate-resistant acid phosphatase type 5
    Names
    TR-AP
    acid phosphatase type V
    tartrate-resistant acid ATPase
    trATPase
    type 5 acid phosphatase
    NP_001257818.1
    NP_062017.2
    XP_006242754.1
    XP_006242755.1
    XP_006242756.1
    XP_017450976.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270889.1NP_001257818.1  tartrate-resistant acid phosphatase type 5 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001257818.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      BC078847, BM386942
      UniProtKB/Swiss-Prot
      P29288
      Related
      ENSRNOP00000066364.1, ENSRNOT00000075237.2
      Conserved Domains (2) summary
      cd07378
      Location:28313
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
      pfam00149
      Location:28244
      Metallophos; Calcineurin-like phosphoesterase
    2. NM_019144.2NP_062017.2  tartrate-resistant acid phosphatase type 5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_062017.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC078847, BM386942, CV074238
      UniProtKB/Swiss-Prot
      P29288
      UniProtKB/TrEMBL
      A0A0G2K6Z6
      Related
      ENSRNOP00000074001.1, ENSRNOT00000092200.1
      Conserved Domains (2) summary
      cd07378
      Location:36321
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
      pfam00149
      Location:36252
      Metallophos; Calcineurin-like phosphoesterase

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

      Range
      23142733..23149067 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242693.3XP_006242755.1  tartrate-resistant acid phosphatase type 5 isoform X2

      See identical proteins and their annotated locations for XP_006242755.1

      UniProtKB/Swiss-Prot
      P29288
      Conserved Domains (2) summary
      cd07378
      Location:28313
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
      pfam00149
      Location:28244
      Metallophos; Calcineurin-like phosphoesterase
    2. XM_006242692.3XP_006242754.1  tartrate-resistant acid phosphatase type 5 isoform X2

      See identical proteins and their annotated locations for XP_006242754.1

      UniProtKB/Swiss-Prot
      P29288
      Conserved Domains (2) summary
      cd07378
      Location:28313
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
      pfam00149
      Location:28244
      Metallophos; Calcineurin-like phosphoesterase
    3. XM_017595487.1XP_017450976.1  tartrate-resistant acid phosphatase type 5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6Z6
      Conserved Domains (2) summary
      cd07378
      Location:36321
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
      pfam00149
      Location:36252
      Metallophos; Calcineurin-like phosphoesterase
    4. XM_006242694.2XP_006242756.1  tartrate-resistant acid phosphatase type 5 isoform X2

      See identical proteins and their annotated locations for XP_006242756.1

      UniProtKB/Swiss-Prot
      P29288
      Conserved Domains (2) summary
      cd07378
      Location:28313
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
      pfam00149
      Location:28244
      Metallophos; Calcineurin-like phosphoesterase

    Alternate Rn_Celera

    Genomic

    1. AC_000076.1 Alternate Rn_Celera

      Range
      22052728..22058674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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