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    Itgb4 integrin subunit beta 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25724, updated on 19-Apr-2019

    Summary

    Official Symbol
    Itgb4provided by RGD
    Official Full Name
    integrin subunit beta 4provided by RGD
    Primary source
    RGD:2928
    See related
    Ensembl:ENSRNOG00000005580
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    beta subunit of integrin alpha6/beta4 which is a cell surface receptor for laminin; involved in hemidesmosome formation [RGD, Feb 2006]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Thymus (RPKM 62.0), Muscle (RPKM 43.9) and 9 other tissues See more
    Orthologs

    Genomic context

    See Itgb4 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (104524000..104560180)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (103725179..103761358, complement)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene SAP30 binding protein Neighboring gene ribosomal protein S18-like 1 Neighboring gene galactokinase 1 Neighboring gene H3 histone family member 3B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell adhesion molecule binding TAS
    Traceable Author Statement
    more info
    PubMed 
    insulin-like growth factor I binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to insulin-like growth factor I binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    contributes_to insulin-like growth factor I binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuregulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to neuregulin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    contributes_to neuregulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    amelogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    amelogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    autophagy ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell motility IEA
    Inferred from Electronic Annotation
    more info
     
    cell motility ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    digestive tract development IEA
    Inferred from Electronic Annotation
    more info
     
    digestive tract development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hemidesmosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    hemidesmosome assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    integrin-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    mesodermal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    mesodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    myelination in peripheral nervous system ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nail development IEA
    Inferred from Electronic Annotation
    more info
     
    nail development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peripheral nervous system myelin formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    renal system development IEA
    Inferred from Electronic Annotation
    more info
     
    renal system development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to wounding IEA
    Inferred from Electronic Annotation
    more info
     
    response to wounding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to wounding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    skin development IEA
    Inferred from Electronic Annotation
    more info
     
    skin development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    trophoblast cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    basement membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell leading edge IEA
    Inferred from Electronic Annotation
    more info
     
    cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell leading edge ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hemidesmosome IEA
    Inferred from Electronic Annotation
    more info
     
    hemidesmosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integrin complex IEA
    Inferred from Electronic Annotation
    more info
     
    integrin complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integrin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    integrin beta-4
    Names
    GP150

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013180.1NP_037312.1  integrin beta-4 precursor

      See identical proteins and their annotated locations for NP_037312.1

      Status: PROVISIONAL

      Source sequence(s)
      U60096
      UniProtKB/Swiss-Prot
      Q64632
      Related
      ENSRNOP00000073188.1, ENSRNOT00000086747.1
      Conserved Domains (6) summary
      smart00237
      Location:9921086
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:12221315
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:16261711
      fn3; Fibronectin type III domain
      pfam00362
      Location:37454
      Integrin_beta; Integrin, beta chain
      pfam07965
      Location:628712
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:544574
      EGF_2; EGF-like domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      104524000..104560180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      99781746..99817137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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