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    Smad1 SMAD family member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25671, updated on 19-Apr-2019

    Summary

    Official Symbol
    Smad1provided by RGD
    Official Full Name
    SMAD family member 1provided by RGD
    Primary source
    RGD:3030
    See related
    Ensembl:ENSRNOG00000018483
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Madh1
    Summary
    a transcriptional activator; activated by bone morphogenetic protein 4 (BMP4) [RGD, Feb 2006]
    Expression
    Biased expression in Lung (RPKM 65.7), Heart (RPKM 64.3) and 9 other tissues See more
    Orthologs

    Genomic context

    See Smad1 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (32182942..32248694)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (43079695..43145300)

    Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene cytosolic purine 5'-nucleotidase-like Neighboring gene mitochondrial ribosomal protein S36-like Neighboring gene metabolism of cobalamin associated A Neighboring gene uncharacterized LOC102550010 Neighboring gene LOC498933

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DEAD/H-box RNA helicase binding IEA
    Inferred from Electronic Annotation
    more info
     
    DEAD/H-box RNA helicase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    I-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    I-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    co-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    co-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    primary miRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    primary miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    SMAD protein complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    SMAD protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    bone development IEA
    Inferred from Electronic Annotation
    more info
     
    bone development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cardiac muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    cartilage development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to BMP stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    embryonic pattern specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    gamete generation IEA
    Inferred from Electronic Annotation
    more info
     
    gamete generation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hindbrain development IEA
    Inferred from Electronic Annotation
    more info
     
    hindbrain development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    homeostatic process IEA
    Inferred from Electronic Annotation
    more info
     
    homeostatic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    kidney development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    mesodermal cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    mesodermal cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    midbrain development IEA
    Inferred from Electronic Annotation
    more info
     
    midbrain development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of muscle cell apoptotic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    osteoblast fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast fate commitment ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cartilage development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of dendrite morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of pri-miRNA transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of pri-miRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to organonitrogen compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
     
    ureteric bud development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    wound healing IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    mothers against decapentaplegic homolog 1
    Names
    MAD (mothers against decapentaplegic, Drosophila) homolog 1
    MAD homolog 1
    MAD homolog1 (mothers against decapentaplegic, Drosophila)
    SMAD 1
    SMAD, mothers against DPP homolog 1
    mothers against DPP homolog 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013130.2NP_037262.2  mothers against decapentaplegic homolog 1

      See identical proteins and their annotated locations for NP_037262.2

      Status: PROVISIONAL

      Source sequence(s)
      BC061757
      UniProtKB/TrEMBL
      Q6P7A6
      Related
      ENSRNOP00000025079.4, ENSRNOT00000025079.6
      Conserved Domains (3) summary
      cd10490
      Location:9132
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:268468
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
      pfam17093
      Location:185237
      PBP_N; Penicillin-binding protein N-terminus

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

      Range
      32182942..32248694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255396.3XP_006255458.1  mothers against decapentaplegic homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006255458.1

      Conserved Domains (3) summary
      cd10490
      Location:9132
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:283483
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
      pfam17093
      Location:185237
      PBP_N; Penicillin-binding protein N-terminus
    2. XM_006255394.1XP_006255456.1  mothers against decapentaplegic homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006255456.1

      Conserved Domains (3) summary
      cd10490
      Location:9132
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:283483
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
      pfam17093
      Location:185237
      PBP_N; Penicillin-binding protein N-terminus
    3. XM_006255397.1XP_006255459.1  mothers against decapentaplegic homolog 1 isoform X2

      Conserved Domains (3) summary
      cd10490
      Location:9132
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:276476
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
      pfam17093
      Location:185237
      PBP_N; Penicillin-binding protein N-terminus
    4. XM_006255395.3XP_006255457.1  mothers against decapentaplegic homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006255457.1

      Conserved Domains (3) summary
      cd10490
      Location:9132
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:283483
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
      pfam17093
      Location:185237
      PBP_N; Penicillin-binding protein N-terminus

    Alternate Rn_Celera

    Genomic

    1. AC_000087.1 Alternate Rn_Celera

      Range
      28023055..28083575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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