Format

Send to:

Choose Destination
    • Showing Current items.

    Oaz1 ornithine decarboxylase antizyme 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25502, updated on 18-Apr-2019

    Summary

    Official Symbol
    Oaz1provided by RGD
    Official Full Name
    ornithine decarboxylase antizyme 1provided by RGD
    Primary source
    RGD:3219
    See related
    Ensembl:ENSRNOG00000019459
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Oaz; ODCAC; ODC-Az
    Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]
    Expression
    Biased expression in Muscle (RPKM 2001.1), Heart (RPKM 1859.0) and 9 other tissues See more
    Orthologs

    Genomic context

    See Oaz1 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11752127..11754587, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (11919843..11922300, complement)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene leucine rich repeat and Ig domain containing 3 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene junctional sarcoplasmic reticulum protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enzyme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ornithine decarboxylase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ornithine decarboxylase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ornithine decarboxylase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    ornithine decarboxylase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of polyamine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of polyamine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    polyamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    polyamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ornithine decarboxylase antizyme 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297557.1NP_001284486.1  ornithine decarboxylase antizyme 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms resulting from the use of alternative in-frame translation initiation codons. The longer isoform (1, also known as 29 kDa form or AZ-1) is derived from an upstream AUG (at nt 80-82), whereas the shorter isoform (2, also known as 24.5 kDa form or AZ-2) is derived from a downstream AUG (at nt 179-181). This RefSeq represents the shorter isoform, which is found in the cytosol (PMID:16120325).
      Source sequence(s)
      FQ216817
      Conserved Domains (1) summary
      pfam02100
      Location:106185
      ODC_AZ; Ornithine decarboxylase antizyme
    2. NM_001301048.1NP_001287977.1  ornithine decarboxylase antizyme 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (3) lacks 2 internal amino acids compared to isoform 1.
      Source sequence(s)
      FQ216817
      Conserved Domains (1) summary
      pfam02100
      Location:137216
      ODC_AZ; Ornithine decarboxylase antizyme
    3. NM_139081.2NP_620781.1  ornithine decarboxylase antizyme 1 isoform 1

      See identical proteins and their annotated locations for NP_620781.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms resulting from the use of alternative in-frame translation initiation codons. The longer isoform (1, also known as 29 kDa form or AZ-1) is derived from an upstream AUG (at nt 80-82), whereas the shorter isoform (2, also known as 24.5 kDa form or AZ-2) is derived from a downstream AUG (at nt 179-181). This RefSeq represents the longer isoform, which is localized to the mitochondria (PMID:16120325).
      Source sequence(s)
      FQ216817
      UniProtKB/Swiss-Prot
      P54370
      Related
      ENSRNOP00000026341.3, ENSRNOT00000026341.5
      Conserved Domains (1) summary
      pfam02100
      Location:139218
      ODC_AZ; Ornithine decarboxylase antizyme

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      11752127..11754587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      7067977..7070437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center