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    trx1 cytosolic thioredoxin Trx1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542084, updated on 11-Apr-2024

    Summary

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    Gene symbol
    trx1
    Gene description
    cytosolic thioredoxin Trx1
    Primary source
    PomBase:SPAC7D4.07c
    Locus tag
    SPAC7D4.07c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2625316..2625855)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene putative steroid dehydrogenase Neighboring gene uncharacterized protein Neighboring gene putative oligosaccharyltransferase subunit Ost4 Neighboring gene putative dolichol-P-Man-dependent alpha(1-3) mannosyltransferase Alg3 Neighboring gene putative hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role and regulation of Trxl, a cytosolic thioredoxin in Schizosaccharomyces pombe. Song JY, et al. J Microbiol, 2008 Aug. PMID 18758731
    2. Characterization and regulation of Schizosaccharomyces pombe gene encoding thioredoxin. Cho Y, et al. Biochim Biophys Acta, 2001 Mar 19. PMID 11267679
    3. Characterization and regulation of a second gene encoding thioredoxin from the fission yeast. Lee YJ, et al. Biochim Biophys Acta, 2002 May 3. PMID 12020831
    4. Gpx1 is a stationary phase-specific thioredoxin peroxidase in fission yeast. Lee SY, et al. Biochem Biophys Res Commun, 2008 Feb 29. PMID 18162174
    5. Glutathione reductase and a mitochondrial thioredoxin play overlapping roles in maintaining iron-sulfur enzymes in fission yeast. Song JY, et al. Eukaryot Cell, 2006 Nov. PMID 16950927, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We propose that in a mutant strain compromised in reducing equivalents, the absence of an abundant and competitive substrate such as the peroxiredoxin Tpx1 has been selected as a lethality suppressor to favor RNR function at the expense of the non-essential peroxide scavenging function, to allow DNA synthesis and cell growth.
      Title: Lack of a peroxiredoxin suppresses the lethality of cells devoid of electron donors by channelling electrons to oxidized ribonucleotide reductase.
    2. our data establish that redox-coupling between Trx1 and the thioredoxin peroxidase activity of Tpx1 is central for initiation of appropriate responses to different levels of hydrogen peroxide in S. pombe
      Title: Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival.
    3. Trxl plays a major role in protecting S. pombe against various stressful conditions and enables proper sulfur metabolism.
      Title: The role and regulation of Trxl, a cytosolic thioredoxin in Schizosaccharomyces pombe.
    4. These results indicate that glutathione reductase is essential in the aerobic growth of S. pombe due to its role in maintaining oxidation-labile Fe-S enzymes and iron homeostasis through mitochondrial thioredoxin Trx2.
      Title: Glutathione reductase and a mitochondrial thioredoxin play overlapping roles in maintaining iron-sulfur enzymes in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables antioxidant activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-disulfide reductase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein-disulfide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-disulfide reductase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein-disulfide reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-methionine salvage from methionine sulphoxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular detoxification of hydrogen peroxide IC
    Inferred by Curator
    more info
    		  
    involved_in cellular response to reactive oxygen species IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in hydrogen peroxide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    cytosolic thioredoxin Trx1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2625316..2625855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019281.2 → NP_593852.1  cytosolic thioredoxin Trx1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593852.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14463, P58265, Q9UTS9
      Conserved Domains (1) summary
      cd02947
      Location:9 → 100
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    Nucleotide Protein
    Heading Accession and Version

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