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    Arrb2 arrestin, beta 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25388, updated on 15-Apr-2019

    Summary

    Official Symbol
    Arrb2provided by RGD
    Official Full Name
    arrestin, beta 2provided by RGD
    Primary source
    RGD:2157
    See related
    Ensembl:ENSRNOG00000019308
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BARRES
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Thymus (RPKM 253.6), Spleen (RPKM 193.9) and 9 other tissues See more
    Orthologs

    Genomic context

    See Arrb2 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57040252..57048045)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (56797489..56805282)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene arachidonate 15-lipoxygenase Neighboring gene proline, glutamate and leucine rich protein 1 Neighboring gene mediator complex subunit 11 Neighboring gene C-X-C motif chemokine ligand 16 Neighboring gene zinc finger, MYND-type containing 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC105502

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    14-3-3 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    D1 dopamine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    alpha-1A adrenergic receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    alpha-1B adrenergic receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiotensin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    arrestin family protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    follicle-stimulating hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    mitogen-activated protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    platelet activating factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase B binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase B binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    type 1 angiotensin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    type 2A serotonin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT type 2A serotonin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    G protein-coupled receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adult walking behavior IEA
    Inferred from Electronic Annotation
    more info
     
    adult walking behavior ISO
    Inferred from Sequence Orthology
    more info
     
    brain development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    desensitization of G protein-coupled receptor signaling pathway by arrestin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    desensitization of G protein-coupled receptor signaling pathway by arrestin ISO
    Inferred from Sequence Orthology
    more info
     
    detection of temperature stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    follicle-stimulating hormone signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-1 beta production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of natural killer cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of smooth muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cardiac muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of collagen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission, dopaminergic IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of synaptic transmission, dopaminergic ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of androgen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    endocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012911.1NP_037043.1  beta-arrestin-2

      See identical proteins and their annotated locations for NP_037043.1

      Status: PROVISIONAL

      Source sequence(s)
      M91590
      UniProtKB/Swiss-Prot
      P29067
      Related
      ENSRNOP00000026207.6, ENSRNOT00000026207.7
      Conserved Domains (2) summary
      smart01017
      Location:199350
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:19175
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      57040252..57048045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      54285120..54301063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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