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    Pcsk1 proprotein convertase subtilisin/kexin type 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25204, updated on 18-Apr-2019

    Summary

    Official Symbol
    Pcsk1provided by RGD
    Official Full Name
    proprotein convertase subtilisin/kexin type 1provided by RGD
    Primary source
    RGD:3272
    See related
    Ensembl:ENSRNOG00000011107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BDP; PC1; PC3
    Summary
    plays a role in proteolytic processing of peptide hormone and other protein precursors [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 49.8), Spleen (RPKM 29.7) and 8 other tissues See more
    Orthologs

    Genomic context

    See Pcsk1 in Genome Data Viewer
    Location:
    2q23
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (91450162..91497091, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (2274882..2309886)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene similar to heat shock protein 2 Neighboring gene similar to Transcription factor Spi-C (Pu.1-related factor) (Prf) Neighboring gene uncharacterized LOC102548697 Neighboring gene hypothetical LOC100361638 Neighboring gene N-alpha-acetyltransferase 11-like Neighboring gene GTPase activating protein testicular GAP1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    insulin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    neurogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    pancreas development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    peptide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptide hormone processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptide hormone processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide hormone processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptide hormone processing ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    pituitary gland development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of protein secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autoprocessing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein processing ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to axon injury IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to calcium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to chlorate IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to fatty acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to inorganic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to morphine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neuroendocrine convertase 1
    Names
    NEC 1
    Protein convertase subtilisin / kexin, type I
    prohormone convertase 1
    prohormone convertase 3
    proprotein convertase 1
    NP_058787.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017091.2NP_058787.1  neuroendocrine convertase 1 precursor

      See identical proteins and their annotated locations for NP_058787.1

      Status: VALIDATED

      Source sequence(s)
      AC091242, M76705, M83745
      UniProtKB/Swiss-Prot
      P28840
      Related
      ENSRNOP00000015185.2, ENSRNOT00000015185.3
      Conserved Domains (5) summary
      cd04059
      Location:121415
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:158432
      Peptidase_S8; Subtilase family
      pfam01483
      Location:504591
      P_proprotein; Proprotein convertase P-domain
      pfam12177
      Location:714750
      Proho_convert; Prohormone convertase enzyme
      pfam16470
      Location:34110
      S8_pro-domain; Peptidase S8 pro-domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      91450162..91497091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      885989..932918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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