Format

Send to:

Choose Destination
    • Showing Current items.

    Syk spleen associated tyrosine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25155, updated on 19-Apr-2019

    Summary

    Official Symbol
    Sykprovided by RGD
    Official Full Name
    spleen associated tyrosine kinaseprovided by RGD
    Primary source
    RGD:3796
    See related
    Ensembl:ENSRNOG00000012160
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    p72syk
    Summary
    plays a role in cCbl-mediated ubiquitination and down-regulation by protein degradation of FcepsilonRI, a high affinity receptor for IgE [RGD, Feb 2006]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Spleen (RPKM 486.2), Thymus (RPKM 76.4) and 4 other tissues See more
    Orthologs

    Genomic context

    See Syk in Genome Data Viewer
    Location:
    17p14
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (12614311..12669568, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (14703903..14759160, complement)

    Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene AU RNA binding methylglutaconyl-CoA hydratase Neighboring gene uncharacterized LOC108348512 Neighboring gene uncharacterized LOC108348513 Neighboring gene uncharacterized LOC103694041

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    SH2 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Toll-like receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Toll-like receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    interleukin-15 receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-15 receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    non-membrane spanning protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    B cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    activation of JUN kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adaptive immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    beta selection IEA
    Inferred from Electronic Annotation
    more info
     
    beta selection ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    blood vessel morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    blood vessel morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to low-density lipoprotein particle stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to low-density lipoprotein particle stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to low-density lipoprotein particle stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to molecule of fungal origin IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to molecule of fungal origin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to molecule of fungal origin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    collagen-activated tyrosine kinase receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    collagen-activated tyrosine kinase receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    defense response to bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enzyme linked receptor protein signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integrin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    interleukin-3-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-3-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    interleukin-3-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    leukocyte activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    leukocyte activation involved in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    leukocyte cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    leukocyte cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    leukotriene biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    leukotriene biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lymph vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    lymph vessel development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lymph vessel development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    macrophage activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    macrophage activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    macrophage activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    macrophage activation involved in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neutrophil activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neutrophil activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neutrophil activation involved in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neutrophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neutrophil chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of B cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of alpha-beta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of alpha-beta T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of alpha-beta T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of alpha-beta T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of bone resorption IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of bone resorption ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell adhesion mediated by integrin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of cytokine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokine secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of gamma-delta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gamma-delta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of interleukin-3 biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-3 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of interleukin-4 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-4 production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of interleukin-4 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of mast cell degranulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mast cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of type I interferon production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of arachidonic acid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of arachidonic acid secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of arachidonic acid secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of neutrophil degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neutrophil degranulation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of neutrophil degranulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of platelet activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of platelet aggregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of platelet aggregation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of platelet aggregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of superoxide anion generation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    serotonin secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    serotonin secretion by platelet IEA
    Inferred from Electronic Annotation
    more info
     
    serotonin secretion by platelet ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    serotonin secretion by platelet ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    B cell receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    B cell receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    T cell receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    T cell receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    early phagosome IEA
    Inferred from Electronic Annotation
    more info
     
    early phagosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    early phagosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    tyrosine-protein kinase SYK
    Names
    spleen tyrosine kinase
    NP_036890.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012758.1NP_036890.1  tyrosine-protein kinase SYK

      See identical proteins and their annotated locations for NP_036890.1

      Status: PROVISIONAL

      Source sequence(s)
      U21684
      UniProtKB/Swiss-Prot
      Q64725
      Related
      ENSRNOP00000016942.3, ENSRNOT00000016942.6
      Conserved Domains (4) summary
      cd05116
      Location:370625
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:12115
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:163261
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:368620
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

      Range
      12614311..12669568 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000085.1 Alternate Rn_Celera

      Range
      12367624..12424213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center