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    Pdgfrb platelet derived growth factor receptor beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24629, updated on 19-Apr-2019

    Summary

    Official Symbol
    Pdgfrbprovided by RGD
    Official Full Name
    platelet derived growth factor receptor betaprovided by RGD
    Primary source
    RGD:3285
    See related
    Ensembl:ENSRNOG00000018461
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PDGFR-1
    Summary
    binds platelet derived growth factor BB homodimer [RGD, Feb 2006]
    Expression
    Biased expression in Kidney (RPKM 224.3), Lung (RPKM 214.5) and 9 other tissues See more
    Orthologs

    Genomic context

    See Pdgfrb in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (56364586..56406381)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (55596682..55637692)

    Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene sodium-dependent proline transporter-like Neighboring gene caudal type homeo box 1 Neighboring gene uncharacterized LOC102555480 Neighboring gene colony stimulating factor 1 receptor Neighboring gene HMG-box containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphatidylinositol 3-kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    platelet-derived growth factor beta-receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    platelet-derived growth factor beta-receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    platelet-derived growth factor beta-receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    platelet-derived growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    platelet-derived growth factor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    platelet-derived growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    platelet-derived growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    platelet-derived growth factor-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    platelet-derived growth factor-activated receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet-derived growth factor-activated receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vascular endothelial growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    vascular endothelial growth factor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    adrenal gland development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    aorta morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    blood vessel development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cardiac myofibril assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cardiac myofibril assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell migration involved in coronary angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell migration involved in coronary angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell migration involved in vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell migration involved in vasculogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to platelet-derived growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic organ development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    glycosaminoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hematopoietic progenitor cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT hemopoiesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    inner ear development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lung growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male gonad development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    metanephric S-shaped body morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    metanephric comma-shaped body morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    metanephric glomerular capillary formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metanephric glomerular capillary formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metanephric glomerular mesangial cell proliferation involved in metanephros development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metanephric glomerular mesangial cell proliferation involved in metanephros development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metanephric glomerular mesangium development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metanephric glomerulus morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    metanephric mesenchymal cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metanephric mesenchyme development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nitrogen compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphatidylinositol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphatidylinositol-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    platelet-derived growth factor receptor-beta signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of DNA biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of calcium ion import ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of collagen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hepatic stellate cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of mitotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phosphatidylinositol 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of phospholipase C activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of reactive oxygen species metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of smooth muscle cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of smooth muscle cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to ceramide ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to fluid shear stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hyperoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    retina vasculature development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    retina vasculature development in camera-type eye ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    smooth muscle cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    smooth muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    tissue homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    wound healing IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lysosomal lumen IEA
    Inferred from Electronic Annotation
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    platelet-derived growth factor receptor beta
    Names
    CD140 antigen-like family member B
    PDGF-R-beta
    PDGFR-beta
    Platelet-derived growth factor receptor, beta
    beta platelet-derived growth factor receptor
    beta-type platelet-derived growth factor receptor
    platelet derived growth factor receptor, beta polypeptide
    platelet-derived growth factor receptor 1
    platelet-derived growth factor receptor beta variant 1
    NP_113713.1
    XP_006254851.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031525.1NP_113713.1  platelet-derived growth factor receptor beta precursor

      See identical proteins and their annotated locations for NP_113713.1

      Status: PROVISIONAL

      Source sequence(s)
      AY090783
      UniProtKB/Swiss-Prot
      Q05030
      Related
      ENSRNOP00000069485.1, ENSRNOT00000086033.1
      Conserved Domains (6) summary
      smart00409
      Location:334412
      IG; Immunoglobulin
      smart00410
      Location:221309
      IG_like; Immunoglobulin like
      pfam00047
      Location:36113
      ig; Immunoglobulin domain
      pfam07714
      Location:599952
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:313414
      Ig; Immunoglobulin domain
      cl21453
      Location:561952
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

      Range
      56364586..56406381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254789.3XP_006254851.1  platelet-derived growth factor receptor beta isoform X1

      See identical proteins and their annotated locations for XP_006254851.1

      UniProtKB/Swiss-Prot
      Q05030
      Related
      ENSRNOP00000060534.1, ENSRNOT00000068535.3
      Conserved Domains (6) summary
      smart00409
      Location:334412
      IG; Immunoglobulin
      smart00410
      Location:221309
      IG_like; Immunoglobulin like
      pfam00047
      Location:36113
      ig; Immunoglobulin domain
      pfam07714
      Location:599952
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:313414
      Ig; Immunoglobulin domain
      cl21453
      Location:561952
      PKc_like; Protein Kinases, catalytic domain

    Alternate Rn_Celera

    Genomic

    1. AC_000086.1 Alternate Rn_Celera

      Range
      52652411..52691218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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