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    Tubb3 tubulin, beta 3 class III [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246118, updated on 19-Mar-2019

    Summary

    Official Symbol
    Tubb3provided by RGD
    Official Full Name
    tubulin, beta 3 class IIIprovided by RGD
    Primary source
    RGD:628595
    See related
    Ensembl:ENSRNOG00000017209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Brain (RPKM 1330.7), Testes (RPKM 116.2) and 1 other tissue See more
    Orthologs

    Genomic context

    See Tubb3 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (56220759..56229813)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (66931880..66940930)

    Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene transcription factor 25 Neighboring gene melanocortin 1 receptor Neighboring gene differentially expressed in FDCP 8 homolog Neighboring gene AFG3(ATPase family gene 3)-like 1 (S. cerevisiae)

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Gap junction, organism-specific biosystem (from KEGG)
      Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Gap junction, conserved biosystem (from KEGG)
      Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    netrin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptide binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    structural constituent of cytoskeleton NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dorsal root ganglion development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule-based process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    netrin-activated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cell periphery IEA
    Inferred from Electronic Annotation
    more info
     
    cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    filopodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tubulin beta-3 chain
    Names
    neuron-specific class III beta-tubulin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139254.2NP_640347.2  tubulin beta-3 chain

      See identical proteins and their annotated locations for NP_640347.2

      Status: VALIDATED

      Source sequence(s)
      BC097281, CF976541
      UniProtKB/Swiss-Prot
      Q4QRB4
      Related
      ENSRNOP00000023452.3, ENSRNOT00000023452.6
      Conserved Domains (1) summary
      PLN00220
      Location:1447
      PLN00220; tubulin beta chain; Provisional

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

      Range
      56220759..56229813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000087.1 Alternate Rn_Celera

      Range
      50689724..50698713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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