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    Nras NRAS proto-oncogene, GTPase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24605, updated on 5-Aug-2018

    Summary

    Official Symbol
    Nrasprovided by RGD
    Official Full Name
    NRAS proto-oncogene, GTPaseprovided by RGD
    Primary source
    RGD:3205
    See related
    Ensembl:ENSRNOG00000023079
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    a GTPase; involved in GTPase mediated signal transduction, may play a role in collagen-induced arthritis in rats [RGD, Feb 2006]
    Expression
    Biased expression in Thymus (RPKM 212.1), Lung (RPKM 203.5) and 9 other tissues See more
    Orthologs

    Genomic context

    See Nras in Genome Data Viewer
    Location:
    2q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (205553119..205563716)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (224983707..224994303)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene complex III assembly factor LYRM7-like Neighboring gene cold shock domain containing E1 Neighboring gene adenosine monophosphate deaminase 1 Neighboring gene DENN domain containing 2C

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    T-helper 1 type immune response ISO
    Inferred from Sequence Orthology
    more info
     
    biological_process ND
    No biological Data available
    more info
     
    defense response to protozoan ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-gamma production ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cellular_component ND
    No biological Data available
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    GTPase NRas
    Names
    neuroblastoma RAS viral (v-ras) oncogene homolog
    neuroblastoma RAS viral oncogene homolog
    neuroblastoma ras oncogene
    transforming protein N-Ras

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080766.2NP_542944.1  GTPase NRas precursor

      See identical proteins and their annotated locations for NP_542944.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098659
      UniProtKB/Swiss-Prot
      Q04970
      Related
      ENSRNOP00000036381.3, ENSRNOT00000039572.3
      Conserved Domains (2) summary
      cd04138
      Location:3164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
      smart00173
      Location:16166
      RAS; Ras subfamily of RAS small GTPases

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      205553119..205563716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233059.2XP_006233121.1  GTPase NRas isoform X1

      See identical proteins and their annotated locations for XP_006233121.1

      UniProtKB/Swiss-Prot
      Q04970
      Conserved Domains (2) summary
      cd04138
      Location:3164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
      smart00173
      Location:16166
      RAS; Ras subfamily of RAS small GTPases

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      183056304..183063940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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