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    Agtr2 angiotensin II receptor, type 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24182, updated on 18-Apr-2019

    Summary

    Official Symbol
    Agtr2provided by RGD
    Official Full Name
    angiotensin II receptor, type 2provided by RGD
    Primary source
    RGD:2072
    See related
    Ensembl:ENSRNOG00000050006
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AT2R; AT2-R; AT<sub>2</sub>R
    Summary
    receptor for angiotensin II; vasodilator that regulates many actions in vascular smooth muscle cells and during development [RGD, Feb 2006]
    Expression
    Biased expression in Adrenal (RPKM 176.0), Uterus (RPKM 25.3) and 3 other tissues See more
    Orthologs

    Genomic context

    See Agtr2 in Genome Data Viewer
    Location:
    Xq34
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (119389480..119393845)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) X NC_005120.3 (119534483..119538667)

    Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 W Neighboring gene similar to hormone-regulated proliferation-associated 20 kDa protein Neighboring gene uncharacterized LOC100911253 Neighboring gene similar to poly(rC) binding protein 2 Neighboring gene hypothetical LOC100363413 Neighboring gene similar to RIKEN cDNA 1110007M04

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G-protein alpha-subunit binding TAS
    Traceable Author Statement
    more info
    PubMed 
    angiotensin type II receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    angiotensin type II receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    angiotensin type II receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger IEA
    Inferred from Electronic Annotation
    more info
     
    G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    aldosterone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    angiotensin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    brain renin-angiotensin system IEA
    Inferred from Electronic Annotation
    more info
     
    brain renin-angiotensin system ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell growth involved in cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to dexamethasone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular sodium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellar cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exploration behavior IEA
    Inferred from Electronic Annotation
    more info
     
    exploration behavior ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    kidney development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    kidney morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of icosanoid secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of neurotrophin TRK receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neurotrophin TRK receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of norepinephrine secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of blood vessel diameter IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of blood vessel diameter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytokine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of metanephric glomerulus development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of metanephric glomerulus development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of nitric-oxide synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of renal sodium excretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of metanephros size IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of metanephros size ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of systemic arterial blood pressure by circulatory renin-angiotensin IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of systemic arterial blood pressure by circulatory renin-angiotensin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    renin-angiotensin regulation of aldosterone production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to organonitrogen compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    vasodilation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    type-2 angiotensin II receptor
    Names
    AT2
    angiotensin II type 2 receptor
    angiotensin receptor 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012494.3NP_036626.1  type-2 angiotensin II receptor

      See identical proteins and their annotated locations for NP_036626.1

      Status: PROVISIONAL

      Source sequence(s)
      U01908
      UniProtKB/Swiss-Prot
      P35351
      UniProtKB/TrEMBL
      B1WBL8
      Conserved Domains (1) summary
      pfam00001
      Location:62318
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

      Range
      119389480..119393845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257432.3XP_006257494.1  type-2 angiotensin II receptor isoform X1

      See identical proteins and their annotated locations for XP_006257494.1

      UniProtKB/Swiss-Prot
      P35351
      UniProtKB/TrEMBL
      B1WBL8
      Related
      ENSRNOP00000064709.1, ENSRNOT00000074269.1
      Conserved Domains (1) summary
      pfam00001
      Location:62318
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate Rn_Celera

    Genomic

    1. AC_000089.1 Alternate Rn_Celera

      Range
      111375374..111376465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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