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    Adcyap1r1 ADCYAP receptor type I [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24167, updated on 18-Apr-2019

    Summary

    Official Symbol
    Adcyap1r1provided by RGD
    Official Full Name
    ADCYAP receptor type Iprovided by RGD
    Primary source
    RGD:2038
    See related
    Ensembl:ENSRNOG00000012098
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PAC1-R; PACAPR1; PACAP-R1; PACAPR1A; PACAP-R1A
    Summary
    regulates neural precursor proliferation; mediates inhibitory signaling for Shh-induced cerebellar granule precursor cell proliferation [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 151.1), Adrenal (RPKM 30.4) and 6 other tissues See more
    Orthologs

    Genomic context

    See Adcyap1r1 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (85662809..85711696)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (150314846..150363650)

    Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551107 Neighboring gene growth hormone releasing hormone receptor Neighboring gene neuronal differentiation 6 Neighboring gene ITPR interacting domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ADP-ribosylation factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adenylate cyclase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuropeptide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vasoactive intestinal polypeptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    activation of phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cAMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    development of primary female sexual characteristics IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    multicellular organismal response to stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cAMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of calcium ion transport into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of inositol phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of small GTPase mediated signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    pituitary adenylate cyclase-activating polypeptide type I receptor
    Names
    ADCYAP receptor type 1
    PACAP type I receptor
    PACAP type IA receptor
    PACAP-R-1
    PACAP-R-1A
    adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
    adenylate cyclase activating polypeptide 1 receptor 1
    adenylate cyclase activating polypeptide 1 receptor type 1
    adenylate cyclase activating polypeptide 1 type 1 receptor
    pituitary adenylate cyclase activating polypeptide 1 receptor (1)
    pituitary adenylate cyclase activating polypeptide receptor
    pituitary adenylate cyclase-activating polypeptide type IA receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270579.1NP_001257508.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform a precursor

      See identical proteins and their annotated locations for NP_001257508.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AABR07073025, CR475040, D16465, Z23272
      UniProtKB/Swiss-Prot
      P32215
      Related
      ENSRNOP00000016175.3, ENSRNOT00000016175.5
      Conserved Domains (2) summary
      pfam00002
      Location:149451
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:51136
      HRM; Hormone receptor domain
    2. NM_001270580.1NP_001257509.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform c precursor

      See identical proteins and their annotated locations for NP_001257509.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant (1). The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AABR07073025, CR475040, D16465, Z23273
      UniProtKB/Swiss-Prot
      P32215
      Related
      ENSRNOP00000050048.2, ENSRNOT00000046192.4
      Conserved Domains (2) summary
      pfam00002
      Location:149423
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:51136
      HRM; Hormone receptor domain
    3. NM_001270581.1NP_001257510.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform d precursor

      See identical proteins and their annotated locations for NP_001257510.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons and differs in the 5' UTR compared to variant (1). The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
      Source sequence(s)
      AABR07073025, CR475040, D14908, D16465
      UniProtKB/Swiss-Prot
      P32215
      Related
      ENSRNOP00000044267.2, ENSRNOT00000043851.3
      Conserved Domains (2) summary
      pfam00002
      Location:149395
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:51136
      HRM; Hormone receptor domain
    4. NM_001270582.1NP_001257511.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform d precursor

      See identical proteins and their annotated locations for NP_001257511.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame exons compared to variant (1). The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
      Source sequence(s)
      AABR07073025, CR475040, D16465, Z23279
      UniProtKB/Swiss-Prot
      P32215
      Conserved Domains (2) summary
      pfam00002
      Location:149395
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:51136
      HRM; Hormone receptor domain
    5. NM_001270583.1NP_001257512.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform e precursor

      See identical proteins and their annotated locations for NP_001257512.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant (1). The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AABR07073025, CR475040, D16465, Z23275
      UniProtKB/Swiss-Prot
      P32215
      Conserved Domains (2) summary
      pfam00002
      Location:149422
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:51136
      HRM; Hormone receptor domain
    6. NM_133511.2NP_598195.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform b precursor

      See identical proteins and their annotated locations for NP_598195.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant (1). The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AABR07073025, CR475040, D16465
      UniProtKB/Swiss-Prot
      P32215
      Related
      ENSRNOP00000030759.2, ENSRNOT00000035722.4
      Conserved Domains (2) summary
      pfam00002
      Location:149423
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:51136
      HRM; Hormone receptor domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

      Range
      85662809..85711696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592431.1XP_017447920.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X2

      UniProtKB/Swiss-Prot
      P32215
      Conserved Domains (2) summary
      pfam00002
      Location:149395
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:51136
      HRM; Hormone receptor domain
    2. XM_017592429.1XP_017447918.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1

      UniProtKB/Swiss-Prot
      P32215
      Conserved Domains (2) summary
      pfam00002
      Location:149423
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:51136
      HRM; Hormone receptor domain
    3. XM_017592430.1XP_017447919.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1

      UniProtKB/Swiss-Prot
      P32215
      Conserved Domains (2) summary
      pfam00002
      Location:149423
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:51136
      HRM; Hormone receptor domain

    Alternate Rn_Celera

    Genomic

    1. AC_000072.1 Alternate Rn_Celera

      Range
      79461538..79510340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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