Format

Send to:

Choose Destination
    • Showing Current items.

    Adcyap1 adenylate cyclase activating polypeptide 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24166, updated on 18-Apr-2019

    Summary

    Official Symbol
    Adcyap1provided by RGD
    Official Full Name
    adenylate cyclase activating polypeptide 1provided by RGD
    Primary source
    RGD:2037
    See related
    Ensembl:ENSRNOG00000049882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pacap
    Summary
    regulatory protein that stimulates cell proliferation, induces differentiation, modulates neurotransmitter release, vasodilation, bronchodilation, and hormone release, and suppresses inflammatory responses [RGD, Feb 2006]
    Expression
    Biased expression in Spleen (RPKM 25.5), Brain (RPKM 22.0) and 1 other tissue See more
    Orthologs

    Genomic context

    See Adcyap1 in Genome Data Viewer
    Location:
    9q38
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (121705897..121725736, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (121155213..121175023, complement)

    Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase D-like 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like Neighboring gene YES proto-oncogene 1, Src family tyrosine kinase Neighboring gene uncharacterized LOC102549764 Neighboring gene thymidylate synthetase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuropeptide hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuropeptide hormone activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptide hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptide hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptide hormone receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    pituitary adenylate cyclase activating polypeptide activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    pituitary adenylate cyclase activating polypeptide activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pituitary adenylate cyclase activating polypeptide activity IEA
    Inferred from Electronic Annotation
    more info
     
    pituitary adenylate cyclase activating polypeptide activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    pituitary adenylate cyclase-activating polypeptide receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pituitary adenylate cyclase-activating polypeptide receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    ATP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    behavioral fear response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cAMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to glucocorticoid stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    histamine secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of acute inflammatory response to antigenic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of acute inflammatory response to non-antigenic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of glial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of muscle cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuropeptide signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuropeptide signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    ovarian follicle development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pituitary gland development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of blood vessel diameter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cAMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of chemokine (C-C motif) ligand 5 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chemokine (C-C motif) ligand 5 production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of growth hormone secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of somatostatin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of synaptic transmission, glutamatergic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of oligodendrocyte progenitor proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of postsynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to starvation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sensory perception of pain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    perikaryon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    pituitary adenylate cyclase-activating polypeptide
    Names
    adenylate cyclase activating polypeptide 1 (pituitary)
    pituitary adenylate cyclase activating polypeptide 1
    pituitary adenylate cyclase-activating polypeptide precursor (Pacap)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016989.2NP_058685.1  pituitary adenylate cyclase-activating polypeptide precursor

      See identical proteins and their annotated locations for NP_058685.1

      Status: VALIDATED

      Source sequence(s)
      BG664825, CB786482, M63006
      UniProtKB/Swiss-Prot
      P13589
      Related
      ENSRNOP00000063920.2, ENSRNOT00000073432.2
      Conserved Domains (1) summary
      pfam00123
      Location:131157
      Hormone_2; Peptide hormone

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

      Range
      121705897..121725736 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767418.2XP_008765640.1  pituitary adenylate cyclase-activating polypeptide isoform X1

      See identical proteins and their annotated locations for XP_008765640.1

      UniProtKB/Swiss-Prot
      P13589
      Conserved Domains (1) summary
      pfam00123
      Location:131157
      Hormone_2; Peptide hormone
    2. XM_006245672.3XP_006245734.1  pituitary adenylate cyclase-activating polypeptide isoform X1

      See identical proteins and their annotated locations for XP_006245734.1

      UniProtKB/Swiss-Prot
      P13589
      Related
      ENSRNOP00000070007.1, ENSRNOT00000087405.1
      Conserved Domains (1) summary
      pfam00123
      Location:131157
      Hormone_2; Peptide hormone
    3. XM_006245674.3XP_006245736.1  pituitary adenylate cyclase-activating polypeptide isoform X1

      See identical proteins and their annotated locations for XP_006245736.1

      UniProtKB/Swiss-Prot
      P13589
      Conserved Domains (1) summary
      pfam00123
      Location:131157
      Hormone_2; Peptide hormone
    4. XM_006245673.3XP_006245735.1  pituitary adenylate cyclase-activating polypeptide isoform X1

      See identical proteins and their annotated locations for XP_006245735.1

      UniProtKB/Swiss-Prot
      P13589
      Conserved Domains (1) summary
      pfam00123
      Location:131157
      Hormone_2; Peptide hormone

    Alternate Rn_Celera

    Genomic

    1. AC_000077.1 Alternate Rn_Celera

      Range
      110207950..110213150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center