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    Pde4d phosphodiesterase 4D, cAMP specific [ Mus musculus (house mouse) ]

    Gene ID: 238871, updated on 31-Jan-2019

    Summary

    Official Symbol
    Pde4dprovided by MGI
    Official Full Name
    phosphodiesterase 4D, cAMP specificprovided by MGI
    Primary source
    MGI:MGI:99555
    See related
    Ensembl:ENSMUSG00000021699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dpde3; 9630011N22Rik
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 2.7), thymus adult (RPKM 2.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pde4d in Genome Data Viewer
    Location:
    13 D2.1; 13 59.69 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (108654177..109955969)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (109444371..110741682)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32450 Neighboring gene predicted gene, 27572 Neighboring gene ribosomal protein S3A3 Neighboring gene high mobility group box 3 pseudogene Neighboring gene predicted gene, 18923 Neighboring gene microRNA 582 Neighboring gene predicted gene, 32813 Neighboring gene predicted gene, 32703 Neighboring gene uncharacterized LOC108168038 Neighboring gene microRNA 1904 Neighboring gene predicted gene, 32881 Neighboring gene RAB3C, member RAS oncogene family Neighboring gene predicted gene, 41057

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ion channel binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ion channel binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cAMP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to epinephrine stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of relaxation of cardiac muscle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cardiac muscle cell contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cardiac muscle cell contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell communication by electrical coupling involved in cardiac conduction IC
    Inferred by Curator
    more info
    PubMed 
    regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ryanodine-sensitive calcium-release channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    calcium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    voltage-gated calcium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cAMP-specific 3',5'-cyclic phosphodiesterase 4D
    Names
    cAMP-specific phosphodiesterase 4D
    cyclic AMP specific phosphodiesterase PDE4D5A
    dunce
    NP_035186.1
    XP_006517706.1
    XP_006517707.1
    XP_006517708.1
    XP_006517709.1
    XP_006517710.1
    XP_006517711.1
    XP_006517712.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011056.3NP_035186.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D

      See identical proteins and their annotated locations for NP_035186.1

      Status: VALIDATED

      Source sequence(s)
      AC156571, AC161585, AC163650, AC174458, CT025614
      Consensus CDS
      CCDS49359.1
      UniProtKB/Swiss-Prot
      Q01063
      UniProtKB/TrEMBL
      A2RSH1
      Related
      ENSMUSP00000113488.1, ENSMUST00000122041.7
      Conserved Domains (1) summary
      pfam00233
      Location:400641
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      108654177..109955969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517643.1XP_006517706.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1

      UniProtKB/TrEMBL
      E9PVU7
      Related
      ENSMUSP00000112991.1, ENSMUST00000120671.7
      Conserved Domains (1) summary
      pfam00233
      Location:456697
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    2. XM_006517644.2XP_006517707.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

      Related
      ENSMUSP00000121592.1, ENSMUST00000153234.7
      Conserved Domains (1) summary
      pfam00233
      Location:398639
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    3. XM_006517645.3XP_006517708.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X3

      UniProtKB/TrEMBL
      B2KF84
      Related
      ENSMUSP00000114089.1, ENSMUST00000119507.7
      Conserved Domains (1) summary
      pfam00233
      Location:356597
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    4. XM_006517646.3XP_006517709.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X4

      Related
      ENSMUSP00000119583.1, ENSMUST00000135275.7
      Conserved Domains (1) summary
      pfam00233
      Location:339580
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    5. XM_006517647.2XP_006517710.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X5

      See identical proteins and their annotated locations for XP_006517710.1

      UniProtKB/Swiss-Prot
      Q01063
      Related
      ENSMUSP00000073742.5, ENSMUST00000074103.11
      Conserved Domains (1) summary
      pfam00233
      Location:331572
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    6. XM_006517649.3XP_006517712.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X7

      See identical proteins and their annotated locations for XP_006517712.1

      UniProtKB/TrEMBL
      A6XDA7
      Related
      ENSMUSP00000113024.1, ENSMUST00000120664.7
      Conserved Domains (1) summary
      pfam00233
      Location:159400
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    7. XM_006517648.3XP_006517711.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X6

      See identical proteins and their annotated locations for XP_006517711.1

      UniProtKB/TrEMBL
      A6XDB0
      Related
      ENSMUSP00000113610.1, ENSMUST00000117420.7
      Conserved Domains (1) summary
      pfam00233
      Location:170411
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
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