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    ACOT9 acyl-CoA thioesterase 9 [ Homo sapiens (human) ]

    Gene ID: 23597, updated on 15-Apr-2019

    Summary

    Official Symbol
    ACOT9provided by HGNC
    Official Full Name
    acyl-CoA thioesterase 9provided by HGNC
    Primary source
    HGNC:HGNC:17152
    See related
    Ensembl:ENSG00000123130 MIM:300862
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACATE2; CGI-16; MTACT48; MT-ACT48
    Summary
    The protein encoded by this gene is a mitochondrial acyl-CoA thioesterase of unknown function. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
    Expression
    Ubiquitous expression in heart (RPKM 10.2), appendix (RPKM 7.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See ACOT9 in Genome Data Viewer
    Location:
    Xp22.11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (23701055..23743290, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (23721777..23784592, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Hikeshi, heat shock protein nuclear import factor pseudogene Neighboring gene patched domain containing 1 Neighboring gene peroxiredoxin 4 Neighboring gene uncharacterized LOC105373148 Neighboring gene spermidine/spermine N1-acetyltransferase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from BioSystems

    • Fatty Acyl-CoA Biosynthesis, organism-specific biosystem (from REACTOME)
      Fatty Acyl-CoA Biosynthesis, organism-specific biosystemFatty acyl-CoA biosynthesis involves following steps: -Palmitate synthesis catalyzed by Acetyl-CoA carboxylase and Fatty acid synthase-Conversion of palmitic acid to long chain fatty acids and-Conver...
    • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
      Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Triglyceride Biosynthesis, organism-specific biosystem (from REACTOME)
      Triglyceride Biosynthesis, organism-specific biosystemThe overall process of triglyceride (triacylglycerol) biosynthesis consists of four biochemical pathways: fatty acyl-CoA biosynthesis, conversion of fatty acyl-CoA to phosphatidic acid, conversion of...
    • acyl-CoA hydrolysis, organism-specific biosystem (from BIOCYC)
      acyl-CoA hydrolysis, organism-specific biosystem
      acyl-CoA hydrolysis

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    acetyl-CoA hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acyl-CoA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acyl-CoA metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    acyl-coenzyme A thioesterase 9, mitochondrial
    Names
    acyl-CoA thioester hydrolase 9
    acyl-Coenzyme A thioesterase 2, mitochondrial
    mitochondrial Acyl-CoA Thioesterase

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016780.2 RefSeqGene

      Range
      5001..44631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001033583.2NP_001028755.2  acyl-coenzyme A thioesterase 9, mitochondrial isoform b precursor

      See identical proteins and their annotated locations for NP_001028755.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK000659, AL548456, BX648512
      Consensus CDS
      CCDS35216.1
      UniProtKB/Swiss-Prot
      Q9Y305
      Related
      ENSP00000336580.7, ENST00000336430.11
      Conserved Domains (1) summary
      cd03442
      Location:286395
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    2. NM_001037171.2NP_001032248.1  acyl-coenzyme A thioesterase 9, mitochondrial isoform a precursor

      See identical proteins and their annotated locations for NP_001032248.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC093011, AL548456, BX648512
      Consensus CDS
      CCDS43924.1
      UniProtKB/Swiss-Prot
      Q9Y305
      Related
      ENSP00000368605.5, ENST00000379303.10
      Conserved Domains (1) summary
      cd03442
      Location:295404
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    3. NM_001330259.1NP_001317188.1  acyl-coenzyme A thioesterase 9, mitochondrial isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC093011, AC131011
      Consensus CDS
      CCDS83460.1
      UniProtKB/Swiss-Prot
      Q9Y305
      Related
      ENSP00000368597.1, ENST00000379295.5

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

      Range
      23701055..23743290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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