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    FOSL2 FOS like 2, AP-1 transcription factor subunit [ Homo sapiens (human) ]

    Gene ID: 2355, updated on 21-Apr-2019

    Summary

    Official Symbol
    FOSL2provided by HGNC
    Official Full Name
    FOS like 2, AP-1 transcription factor subunitprovided by HGNC
    Primary source
    HGNC:HGNC:3798
    See related
    Ensembl:ENSG00000075426 MIM:601575
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FRA2
    Summary
    The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in adrenal (RPKM 58.8), bone marrow (RPKM 50.0) and 23 other tissues See more
    Orthologs

    Genomic context

    See FOSL2 in Genome Data Viewer
    Location:
    2p23.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (28392855..28417312)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (28615704..28637516)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374382 Neighboring gene uncharacterized LOC105374383 Neighboring gene uncharacterized protein FLJ31356 Neighboring gene uncharacterized LOC102723530 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Corticotropin-releasing hormone signaling pathway, organism-specific biosystem (from WikiPathways)
      Corticotropin-releasing hormone signaling pathway, organism-specific biosystemCorticotropin-releasing hormone (CRH) is a neuropeptide secreted abundantly in the paraventricular nucleus of the hypothalamus, amygdala, cerebral cortex and cerebellum in the central nervous system ...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ23306

    General protein information

    Preferred Names
    fos-related antigen 2
    Names
    FOS like 2, AP-1 trancription factor subunit
    FOS like antigen 2
    FRA-2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005253.4NP_005244.1  fos-related antigen 2

      See identical proteins and their annotated locations for NP_005244.1

      Status: REVIEWED

      Source sequence(s)
      AC104695, AK026959, AK055579, BC022791, BM023443, BX647822
      Consensus CDS
      CCDS1766.1
      UniProtKB/Swiss-Prot
      P15408
      UniProtKB/TrEMBL
      Q9H5M2
      Related
      ENSP00000264716.4, ENST00000264716.9
      Conserved Domains (1) summary
      cd14721
      Location:134187
      bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      28392855..28417312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711976.3XP_006712039.1  fos-related antigen 2 isoform X1

      See identical proteins and their annotated locations for XP_006712039.1

      Conserved Domains (1) summary
      cd14721
      Location:134204
      bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
    2. XM_005264231.4XP_005264288.1  fos-related antigen 2 isoform X3

      Conserved Domains (1) summary
      cl21462
      Location:134158
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    3. XM_006711977.3XP_006712040.1  fos-related antigen 2 isoform X2

      See identical proteins and their annotated locations for XP_006712040.1

      Related
      ENSP00000368939.1, ENST00000379619.5
      Conserved Domains (1) summary
      cd14721
      Location:95165
      bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
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