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    ARC activity regulated cytoskeleton associated protein [ Homo sapiens (human) ]

    Gene ID: 23237, updated on 15-Apr-2019

    Summary

    Official Symbol
    ARCprovided by HGNC
    Official Full Name
    activity regulated cytoskeleton associated proteinprovided by HGNC
    Primary source
    HGNC:HGNC:648
    See related
    Ensembl:ENSG00000198576 MIM:612461
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    hArc; Arg3.1
    Expression
    Biased expression in adrenal (RPKM 5.5), brain (RPKM 5.4) and 9 other tissues See more
    Orthologs

    Genomic context

    See ARC in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (142611044..142614472, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143692405..143695833, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor B1 Neighboring gene maestro heat like repeat family member 4, pseudogene Neighboring gene uncharacterized LOC101928087 Neighboring gene Jrk helix-turn-helix protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Amphetamine addiction, organism-specific biosystem (from KEGG)
      Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amphetamine addiction, conserved biosystem (from KEGG)
      Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • BDNF-TrkB Signaling, organism-specific biosystem (from WikiPathways)
      BDNF-TrkB Signaling, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is an important neurotrophin for the regulation of synaptic activity. BDNF-TrkB signaling, TrkB being the receptor of BDNF, is involved in transcription, tran...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0278

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendritic spine morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    endoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    learning IEA
    Inferred from Electronic Annotation
    more info
     
    long-term memory ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    long-term memory TAS
    Traceable Author Statement
    more info
    PubMed 
    long-term synaptic potentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    mRNA transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of AMPA receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of long-term synaptic depression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of long-term synaptic potentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of neuronal synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of postsynaptic neurotransmitter receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle-mediated intercellular transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuronal cell body TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic endosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    activity-regulated cytoskeleton-associated protein
    Names
    ARC/ARG3.1
    activity-regulated gene 3.1 protein homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015193.5NP_056008.1  activity-regulated cytoskeleton-associated protein

      See identical proteins and their annotated locations for NP_056008.1

      Status: VALIDATED

      Source sequence(s)
      AP006547, BC012321
      Consensus CDS
      CCDS34950.1
      UniProtKB/Swiss-Prot
      Q7LC44
      Related
      ENSP00000349022.2, ENST00000356613.4

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

      Range
      142611044..142614472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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