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    Pias3 protein inhibitor of activated STAT 3 [ Mus musculus (house mouse) ]

    Gene ID: 229615, updated on 31-Jan-2019

    Summary

    Official Symbol
    Pias3provided by MGI
    Official Full Name
    protein inhibitor of activated STAT 3provided by MGI
    Primary source
    MGI:MGI:1913126
    See related
    Ensembl:ENSMUSG00000028101
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pias3l
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 15.6), ovary adult (RPKM 8.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pias3 in Genome Data Viewer
    Location:
    3; 3 F2.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (96696375..96706070)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (96500298..96509993)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21, pseudogene 11 Neighboring gene ankyrin repeat domain 35 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 17 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide C Neighboring gene ring finger protein 115

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC27936

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SUMO transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 SUMO-protein ligase PIAS3
    Names
    E3 SUMO-protein transferase PIAS3
    protein inhibitor of activated STAT protein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165949.1NP_001159421.1  E3 SUMO-protein ligase PIAS3 isoform 3

      See identical proteins and their annotated locations for NP_001159421.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses an alternate translational start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      BB042656, BC051252, BE989927, BY154092
      Consensus CDS
      CCDS51007.1
      UniProtKB/Swiss-Prot
      O54714
      Related
      ENSMUSP00000069259.9, ENSMUST00000064900.15
      Conserved Domains (3) summary
      smart00513
      Location:1136
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:323371
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:126263
      PINIT; PINIT domain
    2. NM_018812.2NP_061282.2  E3 SUMO-protein ligase PIAS3 isoform 2

      See identical proteins and their annotated locations for NP_061282.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate translational start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      BB042656, BC050988, BE989927, BY154092
      Consensus CDS
      CCDS17645.2
      UniProtKB/Swiss-Prot
      O54714
      Related
      ENSMUSP00000102692.3, ENSMUST00000107077.3
      Conserved Domains (3) summary
      smart00513
      Location:1136
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:288336
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:91228
      PINIT; PINIT domain
    3. NM_146135.2NP_666247.1  E3 SUMO-protein ligase PIAS3 isoform 1

      See identical proteins and their annotated locations for NP_666247.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK040619, BB042656, BE989927, BY002850
      Consensus CDS
      CCDS38559.1
      UniProtKB/Swiss-Prot
      O54714
      Related
      ENSMUSP00000102691.3, ENSMUST00000107076.9
      Conserved Domains (3) summary
      smart00513
      Location:227
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:314362
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:117254
      PINIT; PINIT domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      96696375..96706070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501393.1XP_006501456.1  E3 SUMO-protein ligase PIAS3 isoform X1

      See identical proteins and their annotated locations for XP_006501456.1

      UniProtKB/Swiss-Prot
      O54714
      Conserved Domains (3) summary
      smart00513
      Location:227
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:314362
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:117254
      PINIT; PINIT domain

    RNA

    1. XR_001783683.1 RNA Sequence

    2. XR_001783684.1 RNA Sequence

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