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    Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 22163, updated on 18-Apr-2019

    Summary

    Official Symbol
    Tnfrsf4provided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 4provided by MGI
    Primary source
    MGI:MGI:104512
    See related
    Ensembl:ENSMUSG00000029075
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ox40; ACT35; CD134; Ly-70; Txgp1; TXGP1L
    Expression
    Broad expression in frontal lobe adult (RPKM 42.7), genital fat pad adult (RPKM 36.8) and 15 other tissues See more
    Orthologs

    Genomic context

    See Tnfrsf4 in Genome Data Viewer
    Location:
    4 E2; 4 87.68 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (156013595..156016613)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (155387804..155390698)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene C1q and tumor necrosis factor related 12 Neighboring gene predicted gene, 42365 Neighboring gene UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6 Neighboring gene stromal cell derived factor 4 Neighboring gene predicted gene 10560 Neighboring gene tumor necrosis factor receptor superfamily, member 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tumor necrosis factor-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tumor necrosis factor-activated receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular defense response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    negative regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of activation-induced cell death of T cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cytokine secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cytokine secretion IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of immunoglobulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tumor necrosis factor receptor superfamily member 4
    Names
    OX40 antigen
    OX40L receptor
    tax-transcriptionally activated glycoprotein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011659.2NP_035789.1  tumor necrosis factor receptor superfamily member 4 precursor

      See identical proteins and their annotated locations for NP_035789.1

      Status: PROVISIONAL

      Source sequence(s)
      AL627204
      Consensus CDS
      CCDS19055.1
      UniProtKB/Swiss-Prot
      P47741
      UniProtKB/TrEMBL
      B1ASL3
      Related
      ENSMUSP00000030952.5, ENSMUST00000030952.5
      Conserved Domains (1) summary
      cd13406
      Location:25168
      TNFRSF4; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      156013595..156016613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538724.3XP_006538787.3  tumor necrosis factor receptor superfamily member 4 isoform X1

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