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    Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) [ Mus musculus (house mouse) ]

    Gene ID: 21355, updated on 16-Apr-2019

    Summary

    Official Symbol
    Tap2provided by MGI
    Official Full Name
    transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)provided by MGI
    Primary source
    MGI:MGI:98484
    See related
    Ensembl:ENSMUSG00000024339
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Y1; jas; APT2; Ham2; MTP2; PSF2; ABC18; Abcb3; Ham-2; Tap-2; RING11; AI462429
    Summary
    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with Tap1 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in thymus adult (RPKM 79.3), spleen adult (RPKM 48.3) and 16 other tissues See more
    Orthologs

    Genomic context

    See Tap2 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (34204479..34216321)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34341424..34353266)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) Neighboring gene proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) Neighboring gene histocompatibility 2, O region beta locus Neighboring gene predicted gene 20506

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (5) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity, coupled to transmembrane movement of substances IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MHC class I protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MHC class I protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to MHC class I protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    MHC class Ib protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    MHC protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    TAP1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    TAP1 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    TAP1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    TAP2 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    TAP2 binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to peptide antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptide antigen-transporting ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to peptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to peptide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptide-transporting ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    tapasin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    antigen processing and presentation of endogenous peptide antigen via MHC class I ISO
    Inferred from Sequence Orthology
    more info
     
    antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent ISO
    Inferred from Sequence Orthology
    more info
     
    antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytosol to ER transport ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    peptide antigen transport ISO
    Inferred from Sequence Orthology
    more info
     
    peptide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptide transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of T cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of antigen processing and presentation of peptide antigen via MHC class I ISO
    Inferred from Sequence Orthology
    more info
     
    protection from natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    response to molecule of bacterial origin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    MHC class I peptide loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    TAP complex ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    antigen peptide transporter 2
    Names
    ATP dependent transport protein family member
    ATP-binding cassette sub-family B member 3
    ATP-binding cassette, sub-family B (MDR/TAP), member 3
    histocompatibility antigen modifier 2
    transporter 2 ATP-binding cassette sub-family B
    transporter 2, ABC (ATP binding cassette)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011530.3NP_035660.3  antigen peptide transporter 2

      See identical proteins and their annotated locations for NP_035660.3

      Status: REVIEWED

      Source sequence(s)
      BE691532, CJ046345, M90459
      Consensus CDS
      CCDS28644.1
      UniProtKB/Swiss-Prot
      P36371
      UniProtKB/TrEMBL
      Q792S7
      Related
      ENSMUSP00000025197.5, ENSMUST00000025197.5
      Conserved Domains (3) summary
      TIGR00958
      Location:1696
      3a01208; Conjugate Transporter-2 (CT2) Family protein
      pfam00664
      Location:155415
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:456679
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      34204479..34216321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 129X1/SvJ

    Genomic

    1. NT_039662.3 Reference GRCm38.p4 129X1/SvJ

      Range
      453397..465239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187027.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      515822..527798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/ShiLtJ

    Genomic

    1. NT_187004.1 Reference GRCm38.p4 NOD/ShiLtJ

      Range
      515955..527931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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