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    Src Rous sarcoma oncogene [ Mus musculus (house mouse) ]

    Gene ID: 20779, updated on 2-Apr-2019

    Summary

    Official Symbol
    Srcprovided by MGI
    Official Full Name
    Rous sarcoma oncogeneprovided by MGI
    Primary source
    MGI:MGI:98397
    See related
    Ensembl:ENSMUSG00000027646
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW259666; pp60c-src
    Expression
    Ubiquitous expression in duodenum adult (RPKM 49.0), colon adult (RPKM 48.4) and 23 other tissues See more
    Orthologs

    Genomic context

    See Src in Genome Data Viewer
    Location:
    2 H1; 2 78.35 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (157423901..157471838)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (157250029..157297574)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39974 Neighboring gene mannosidase, beta A, lysosomal-like Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene bladder cancer associated protein Neighboring gene neuronatin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    connexin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    insulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of protein kinase B activity ISO
    Inferred from Sequence Orthology
    more info
     
    adherens junction organization ISO
    Inferred from Sequence Orthology
    more info
     
    angiotensin-activated signaling pathway involved in heart process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    bone resorption IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in mammary gland duct morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to fluid shear stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to peptide hormone stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to platelet-derived growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to progesterone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to reactive oxygen species IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to transforming growth factor beta stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    forebrain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    neurotrophin TRK receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    odontogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osteoclast development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    osteoclast development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytokine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lamellipodium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of podosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of podosome assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to nucleus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein processing IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    primary ovarian follicle growth ISO
    Inferred from Sequence Orthology
    more info
     
    progesterone receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    progesterone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of caveolin-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell projection assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of intracellular estrogen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of postsynaptic neurotransmitter receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcytosis ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    uterus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    caveola ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    podosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic specialization, intracellular component ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    neuronal proto-oncogene tyrosine-protein kinase Src
    Names
    p60-Src
    proto-oncogene c-Src
    NP_001020566.1
    NP_033297.2
    XP_006499126.1
    XP_006499128.1
    XP_006499129.1
    XP_011237704.1
    XP_011237705.1
    XP_011237706.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025395.2NP_001020566.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform 2

      See identical proteins and their annotated locations for NP_001020566.1

      Status: VALIDATED

      Source sequence(s)
      AL672259, CD355175, CX218263, M17031
      Consensus CDS
      CCDS16978.1
      UniProtKB/Swiss-Prot
      P05480
      UniProtKB/TrEMBL
      F8WI90
      Related
      ENSMUSP00000029175.7, ENSMUST00000029175.13
      Conserved Domains (3) summary
      cd10365
      Location:146246
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:87142
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:259535
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    2. NM_009271.3NP_033297.2  neuronal proto-oncogene tyrosine-protein kinase Src isoform 1

      See identical proteins and their annotated locations for NP_033297.2

      Status: VALIDATED

      Source sequence(s)
      AL672259, CD355175, CX218263, M17031
      Consensus CDS
      CCDS38305.1
      UniProtKB/Swiss-Prot
      P05480
      Related
      ENSMUSP00000090237.4, ENSMUST00000092576.10
      Conserved Domains (4) summary
      cd10365
      Location:152252
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:87148
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:265541
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
      pfam07714
      Location:275524
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      157423901..157471838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239404.1XP_011237706.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

      See identical proteins and their annotated locations for XP_011237706.1

      Conserved Domains (4) summary
      cd10365
      Location:163263
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:87159
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:276552
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
      pfam07714
      Location:286535
      Pkinase_Tyr; Protein tyrosine kinase
    2. XM_006499066.2XP_006499129.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

      See identical proteins and their annotated locations for XP_006499129.1

      Conserved Domains (4) summary
      cd10365
      Location:163263
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:87159
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:276552
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
      pfam07714
      Location:286535
      Pkinase_Tyr; Protein tyrosine kinase
    3. XM_011239402.2XP_011237704.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

      See identical proteins and their annotated locations for XP_011237704.1

      Conserved Domains (4) summary
      cd10365
      Location:163263
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:87159
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:276552
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
      pfam07714
      Location:286535
      Pkinase_Tyr; Protein tyrosine kinase
    4. XM_011239403.2XP_011237705.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

      See identical proteins and their annotated locations for XP_011237705.1

      Conserved Domains (4) summary
      cd10365
      Location:163263
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:87159
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:276552
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
      pfam07714
      Location:286535
      Pkinase_Tyr; Protein tyrosine kinase
    5. XM_006499063.3XP_006499126.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

      See identical proteins and their annotated locations for XP_006499126.1

      Conserved Domains (4) summary
      cd10365
      Location:163263
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:87159
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:276552
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
      pfam07714
      Location:286535
      Pkinase_Tyr; Protein tyrosine kinase
    6. XM_006499065.3XP_006499128.1  neuronal proto-oncogene tyrosine-protein kinase Src isoform X1

      See identical proteins and their annotated locations for XP_006499128.1

      Conserved Domains (4) summary
      cd10365
      Location:163263
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:87159
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:276552
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
      pfam07714
      Location:286535
      Pkinase_Tyr; Protein tyrosine kinase
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