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    Rasgrp1 RAS guanyl releasing protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 19419, updated on 16-Apr-2019

    Summary

    Official Symbol
    Rasgrp1provided by MGI
    Official Full Name
    RAS guanyl releasing protein 1provided by MGI
    Primary source
    MGI:MGI:1314635
    See related
    Ensembl:ENSMUSG00000027347
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rasgrp; calDAG-GEFII
    Expression
    Biased expression in frontal lobe adult (RPKM 49.5), cortex adult (RPKM 48.8) and 5 other tissues See more
    Orthologs

    Genomic context

    See Rasgrp1 in Genome Data Viewer
    Location:
    2 E5; 2 59.19 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (117279993..117342877, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (117105729..117168613, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RAS related protein 1a, pseudogene 2 Neighboring gene family with sequence similarity 98, member B Neighboring gene predicted gene, 32020 Neighboring gene predicted gene 13982

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Targeted (3)  1 citation
    • Chemically induced (ENU) (7) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Ras guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    diacylglycerol binding ISO
    Inferred from Sequence Orthology
    more info
     
    guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    activation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response to antigenic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    mast cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of granulocyte macrophage colony-stimulating factor production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-gamma secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of natural killer cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of natural killer cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of phosphatidylinositol 3-kinase signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    secretory granule localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RAS guanyl-releasing protein 1
    Names
    calcium and DAG-regulated guanine nucleotide exchange factor II

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011246.3NP_035376.1  RAS guanyl-releasing protein 1

      See identical proteins and their annotated locations for NP_035376.1

      Status: VALIDATED

      Source sequence(s)
      BC057341, BE991595
      Consensus CDS
      CCDS16572.1
      UniProtKB/Swiss-Prot
      Q9Z1S3
      Related
      ENSMUSP00000099593.4, ENSMUST00000102534.10
      Conserved Domains (5) summary
      smart00147
      Location:201437
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:54176
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00051
      Location:474521
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:542591
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:478526
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      117279993..117342877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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