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    Rad1 RAD1 checkpoint DNA exonuclease [ Mus musculus (house mouse) ]

    Gene ID: 19355, updated on 31-Jan-2019

    Summary

    Official Symbol
    Rad1provided by MGI
    Official Full Name
    RAD1 checkpoint DNA exonucleaseprovided by MGI
    Primary source
    MGI:MGI:1316678
    See related
    Ensembl:ENSMUSG00000022248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mRAD1
    Expression
    Ubiquitous expression in bladder adult (RPKM 3.3), liver E14 (RPKM 2.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rad1 in Genome Data Viewer
    Location:
    15; 15 A1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (10486018..10499063)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (10415789..10423446)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C21 Neighboring gene BRX1, biogenesis of ribosomes Neighboring gene tetratricopeptide repeat domain 23-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3'-5' exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    3'-5' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    exodeoxyribonuclease III activity IEA
    Inferred from Electronic Annotation
    more info
     
    exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA damage checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    meiotic recombination checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    checkpoint clamp complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cell cycle checkpoint protein RAD1
    Names
    DNA repair exonuclease rad1 homolog
    RAD1 homolog
    rad1-like DNA damage checkpoint protein
    NP_001276376.1
    NP_001276377.1
    NP_035362.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289447.1NP_001276376.1  cell cycle checkpoint protein RAD1 isoform 1

      See identical proteins and their annotated locations for NP_001276376.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1)
      Source sequence(s)
      AC102101
      Consensus CDS
      CCDS27379.1
      UniProtKB/Swiss-Prot
      Q9QWZ1
      Conserved Domains (2) summary
      cd00577
      Location:19276
      PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
      pfam02144
      Location:17257
      Rad1; Repair protein Rad1/Rec1/Rad17
    2. NM_001289448.1NP_001276377.1  cell cycle checkpoint protein RAD1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC102101, AK168588
      Consensus CDS
      CCDS70618.1
      UniProtKB/Swiss-Prot
      Q9QWZ1
      Related
      ENSMUSP00000098338.3, ENSMUST00000100775.9
      Conserved Domains (2) summary
      cd00577
      Location:19228
      PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
      pfam02144
      Location:17222
      Rad1; Repair protein Rad1/Rec1/Rad17
    3. NM_011232.3NP_035362.2  cell cycle checkpoint protein RAD1 isoform 1

      See identical proteins and their annotated locations for NP_035362.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 2 encode the same isoform 1.
      Source sequence(s)
      AC102101, AK150466
      Consensus CDS
      CCDS27379.1
      UniProtKB/Swiss-Prot
      Q9QWZ1
      Related
      ENSMUSP00000022856.8, ENSMUST00000022856.14
      Conserved Domains (2) summary
      cd00577
      Location:19276
      PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
      pfam02144
      Location:17257
      Rad1; Repair protein Rad1/Rec1/Rad17

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      10486018..10499063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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