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    Ptgds prostaglandin D2 synthase (brain) [ Mus musculus (house mouse) ]

    Gene ID: 19215, updated on 19-Mar-2019

    Summary

    Official Symbol
    Ptgdsprovided by MGI
    Official Full Name
    prostaglandin D2 synthase (brain)provided by MGI
    Primary source
    MGI:MGI:99261
    See related
    Ensembl:ENSMUSG00000015090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PGD2; PGDS; 21kDa; PGDS2; Ptgs3; L-PGDS
    Expression
    Biased expression in genital fat pad adult (RPKM 446.8), frontal lobe adult (RPKM 410.4) and 5 other tissues See more
    Orthologs

    Genomic context

    See Ptgds in Genome Data Viewer
    Location:
    2 A3; 2 17.28 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (25466709..25470110, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (25322232..25325269, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family A (ABC1), member 2 Neighboring gene microRNA 3087 Neighboring gene non-homologous end joining factor Neighboring gene chloride intracellular channel 3 Neighboring gene predicted gene, 35287 Neighboring gene lipocalin 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    prostaglandin-D synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    prostaglandin-D synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    retinoid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retinoid binding ISO
    Inferred from Sequence Orthology
    more info
     
    small molecule binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of male germ cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    prostaglandin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    prostaglandin metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of circadian sleep/wake cycle, sleep IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    prostaglandin-H2 D-isomerase
    Names
    PGD2 synthase
    glutathione-independent PGD synthase
    glutathione-independent PGD synthetase
    lipocalin-type prostaglandin-D synthase
    prostaglandin D2 synthase (21 kDa, brain)
    prostaglandin-D2 synthase
    NP_032989.2
    XP_006497849.1
    XP_006497850.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008963.3NP_032989.2  prostaglandin-H2 D-isomerase precursor

      See identical proteins and their annotated locations for NP_032989.2

      Status: VALIDATED

      Source sequence(s)
      AL732557
      Consensus CDS
      CCDS38074.1
      UniProtKB/Swiss-Prot
      O09114
      Related
      ENSMUSP00000015234.6, ENSMUST00000015234.12
      Conserved Domains (1) summary
      pfam00061
      Location:40182
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      25466709..25470110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497787.3XP_006497850.1  prostaglandin-H2 D-isomerase isoform X1

      See identical proteins and their annotated locations for XP_006497850.1

      UniProtKB/Swiss-Prot
      O09114
      Conserved Domains (1) summary
      pfam00061
      Location:40182
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    2. XM_006497786.3XP_006497849.1  prostaglandin-H2 D-isomerase isoform X1

      See identical proteins and their annotated locations for XP_006497849.1

      UniProtKB/Swiss-Prot
      O09114
      Related
      ENSMUSP00000109889.1, ENSMUST00000114251.7
      Conserved Domains (1) summary
      pfam00061
      Location:40182
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
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