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    Pomc pro-opiomelanocortin-alpha [ Mus musculus (house mouse) ]

    Gene ID: 18976, updated on 26-Mar-2019

    Summary

    Official Symbol
    Pomcprovided by MGI
    Official Full Name
    pro-opiomelanocortin-alphaprovided by MGI
    Primary source
    MGI:MGI:97742
    See related
    Ensembl:ENSMUSG00000020660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BE; Npp; ACTH; Clip; Pomc1; Pomc-1; Beta-LPH; alphaMSH; beta-MSH; Gamma-LPH; alpha-MSH; gamma-MSH
    Summary
    This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing. Processing yields several biologically active peptides, which are involved in diverse cellular functions, such as energy homeostasis, steroidogenesis, and increased melanin production in melanocytes. In mouse deficiency of this gene is associated with obesity, defects in adrenal development, and altered pigmentation. A pseudogene of this gene is located on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
    Expression
    Biased expression in testis adult (RPKM 4.3), CNS E14 (RPKM 2.4) and 11 other tissues See more
    Orthologs

    Genomic context

    See Pomc in Genome Data Viewer
    Location:
    12 A1.1; 12 1.99 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (3954945..3960643)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (3954951..3960618)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene DNA methyltransferase 3A Neighboring gene predicted gene, 31623 Neighboring gene peptidyl prolyl isomerase H pseudogene Neighboring gene EFR3 homolog B Neighboring gene DnaJ heat shock protein family (Hsp40) member C27

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (8)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    type 1 melanocortin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    type 3 melanocortin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    type 4 melanocortin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell-cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cellular pigmentation ISO
    Inferred from Sequence Orthology
    more info
     
    generation of precursor metabolites and energy ISO
    Inferred from Sequence Orthology
    more info
     
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of appetite ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood pressure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of corticosterone secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of corticosterone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of glycogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    pro-opiomelanocortin
    Names
    adrenal corticotropic hormone
    adrenocorticotropic hormone
    alpha-melanocyte stimulating hormone
    beta-endorphin
    corticotropin-like intermediary peptide
    corticotropin-lipotropin
    melanotropin gamma
    met-enkephalin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278581.1NP_001265510.1  pro-opiomelanocortin preproprotein

      See identical proteins and their annotated locations for NP_001265510.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AC111092, AW120866, BB022229, BB022936, BB025409, BB026464
      Consensus CDS
      CCDS25785.1
      UniProtKB/Swiss-Prot
      P01193
      Conserved Domains (3) summary
      pfam00976
      Location:186204
      ACTH_domain; Corticotropin ACTH domain
      pfam08035
      Location:205232
      Op_neuropeptide; Opioids neuropeptide
      pfam08384
      Location:2870
      NPP; Pro-opiomelanocortin, N-terminal region
    2. NM_001278582.1NP_001265511.1  pro-opiomelanocortin preproprotein

      See identical proteins and their annotated locations for NP_001265511.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AC111092, AW120866, BB022229, BB022936, BB025409, BB026464
      Consensus CDS
      CCDS25785.1
      UniProtKB/Swiss-Prot
      P01193
      Conserved Domains (3) summary
      pfam00976
      Location:186204
      ACTH_domain; Corticotropin ACTH domain
      pfam08035
      Location:205232
      Op_neuropeptide; Opioids neuropeptide
      pfam08384
      Location:2870
      NPP; Pro-opiomelanocortin, N-terminal region
    3. NM_001278583.1NP_001265512.1  pro-opiomelanocortin preproprotein

      See identical proteins and their annotated locations for NP_001265512.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AC111092, AK030714, BB022936, BB025409, BB026464
      Consensus CDS
      CCDS25785.1
      UniProtKB/Swiss-Prot
      P01193
      Related
      ENSMUSP00000151504.1, ENSMUST00000219543.1
      Conserved Domains (3) summary
      pfam00976
      Location:186204
      ACTH_domain; Corticotropin ACTH domain
      pfam08035
      Location:205232
      Op_neuropeptide; Opioids neuropeptide
      pfam08384
      Location:2870
      NPP; Pro-opiomelanocortin, N-terminal region
    4. NM_001278584.1NP_001265513.1  pro-opiomelanocortin preproprotein

      See identical proteins and their annotated locations for NP_001265513.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AC111092, AK017581, BB025409, BB026464
      Consensus CDS
      CCDS25785.1
      UniProtKB/Swiss-Prot
      P01193
      Related
      ENSMUSP00000151367.1, ENSMUST00000218089.1
      Conserved Domains (3) summary
      pfam00976
      Location:186204
      ACTH_domain; Corticotropin ACTH domain
      pfam08035
      Location:205232
      Op_neuropeptide; Opioids neuropeptide
      pfam08384
      Location:2870
      NPP; Pro-opiomelanocortin, N-terminal region
    5. NM_008895.4NP_032921.1  pro-opiomelanocortin preproprotein

      See identical proteins and their annotated locations for NP_032921.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AC111092, AK017492, AK133646, BB025409
      Consensus CDS
      CCDS25785.1
      UniProtKB/Swiss-Prot
      P01193
      Related
      ENSMUSP00000020990.5, ENSMUST00000020990.6
      Conserved Domains (3) summary
      pfam00976
      Location:186204
      ACTH_domain; Corticotropin ACTH domain
      pfam08035
      Location:205232
      Op_neuropeptide; Opioids neuropeptide
      pfam08384
      Location:2870
      NPP; Pro-opiomelanocortin, N-terminal region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      3954945..3960643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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