Format

Send to:

Choose Destination
    • Showing Current items.

    Oaz1 ornithine decarboxylase antizyme 1 [ Mus musculus (house mouse) ]

    Gene ID: 18245, updated on 31-Jan-2019

    Summary

    Official Symbol
    Oaz1provided by MGI
    Official Full Name
    ornithine decarboxylase antizyme 1provided by MGI
    Primary source
    MGI:MGI:109433
    See related
    Ensembl:ENSMUSG00000035242
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AZ1; Oaz; AZ-1; ODC-Az; Antizyme
    Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 386.0), thymus adult (RPKM 368.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Oaz1 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (80826656..80829290)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (80289401..80292035)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene anti-Mullerian hormone Neighboring gene junctional sarcoplasmic reticulum protein 1 Neighboring gene microRNA 1982 Neighboring gene leucine rich repeat and Ig domain containing 3 Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene signal peptide peptidase like 2B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    ornithine decarboxylase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ornithine decarboxylase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ornithine decarboxylase inhibitor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ornithine decarboxylase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    ornithine decarboxylase inhibitor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ornithine decarboxylase antizyme 1
    Names
    antizyme 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301034.1NP_001287963.1  ornithine decarboxylase antizyme 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) lacks 2 internal amino acids compared to isoform 1.
      Source sequence(s)
      AA270439, AI838943, AK146571, BY112600
      Related
      ENSMUSP00000136469.1, ENSMUST00000177850.7
      Conserved Domains (1) summary
      pfam02100
      Location:128216
      ODC_AZ; Ornithine decarboxylase antizyme
    2. NM_008753.4NP_032779.2  ornithine decarboxylase antizyme 1 isoform 1

      See identical proteins and their annotated locations for NP_032779.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI838943, AK146571, BY112600
      Consensus CDS
      CCDS56736.1
      UniProtKB/Swiss-Prot
      P54369
      Related
      ENSMUSP00000137400.1, ENSMUST00000180036.7
      Conserved Domains (1) summary
      pfam02100
      Location:128218
      ODC_AZ; Ornithine decarboxylase antizyme

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      80826656..80829290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center