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    Nrl neural retina leucine zipper gene [ Mus musculus (house mouse) ]

    Gene ID: 18185, updated on 23-Apr-2019

    Summary

    Official Symbol
    Nrlprovided by MGI
    Official Full Name
    neural retina leucine zipper geneprovided by MGI
    Primary source
    MGI:MGI:102567
    See related
    Ensembl:ENSMUSG00000040632
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D14H14S46E
    Summary
    This gene encodes a member of the basic leucine zipper domain family of transcription factors. The encoded protein is preferentially expressed in the retina and is necessary for rod photoreceptor development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See Nrl in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (55518978..55524981, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (56137815..56143802, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene capping protein regulator and myosin 1 linker 3 Neighboring gene copine VI Neighboring gene phosphoenolpyruvate carboxykinase 2 (mitochondrial) Neighboring gene DDB1 and CUL4 associated factor 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    leucine zipper domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    neural retina-specific leucine zipper protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136074.2NP_001129546.1  neural retina-specific leucine zipper protein

      See identical proteins and their annotated locations for NP_001129546.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC159002, AK044244, AK044316
      Consensus CDS
      CCDS27113.1
      UniProtKB/Swiss-Prot
      P54846
      UniProtKB/TrEMBL
      Q543Y0, Q8C8Y1
      Related
      ENSMUSP00000136445.1, ENSMUST00000178694.2
      Conserved Domains (2) summary
      cd14718
      Location:154223
      bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
      pfam08383
      Location:67101
      Maf_N; Maf N-terminal region
    2. NM_001271916.1NP_001258845.1  neural retina-specific leucine zipper protein

      See identical proteins and their annotated locations for NP_001258845.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC159002, AK044244, AK044275
      Consensus CDS
      CCDS27113.1
      UniProtKB/Swiss-Prot
      P54846
      UniProtKB/TrEMBL
      Q543Y0, Q8C8Y1
      Related
      ENSMUSP00000054457.7, ENSMUST00000062232.14
      Conserved Domains (2) summary
      cd14718
      Location:154223
      bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
      pfam08383
      Location:67101
      Maf_N; Maf N-terminal region
    3. NM_001271917.1NP_001258846.1  neural retina-specific leucine zipper protein

      See identical proteins and their annotated locations for NP_001258846.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC159002, AK044244, AK044316
      Consensus CDS
      CCDS27113.1
      UniProtKB/Swiss-Prot
      P54846
      UniProtKB/TrEMBL
      Q543Y0, Q8C8Y1
      Related
      ENSMUSP00000153933.1, ENSMUST00000228287.1
      Conserved Domains (2) summary
      cd14718
      Location:154223
      bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
      pfam08383
      Location:67101
      Maf_N; Maf N-terminal region
    4. NM_008736.3NP_032762.1  neural retina-specific leucine zipper protein

      See identical proteins and their annotated locations for NP_032762.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC159002, AK044275
      Consensus CDS
      CCDS27113.1
      UniProtKB/Swiss-Prot
      P54846
      UniProtKB/TrEMBL
      Q543Y0
      Related
      ENSMUSP00000107035.1, ENSMUST00000111404.7
      Conserved Domains (2) summary
      cd14718
      Location:154223
      bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
      pfam08383
      Location:67101
      Maf_N; Maf N-terminal region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      55518978..55524981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518688.1XP_006518751.1  neural retina-specific leucine zipper protein isoform X1

      Conserved Domains (1) summary
      cd14718
      Location:56125
      bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
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