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    Nras neuroblastoma ras oncogene [ Mus musculus (house mouse) ]

    Gene ID: 18176, updated on 19-Apr-2019

    Summary

    Official Symbol
    Nrasprovided by MGI
    Official Full Name
    neuroblastoma ras oncogeneprovided by MGI
    Primary source
    MGI:MGI:97376
    See related
    Ensembl:ENSMUSG00000027852
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N-ras; AV095280
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 24.4), placenta adult (RPKM 18.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nras in Genome Data Viewer
    Location:
    3 F2.2; 3 45.25 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (103058285..103067914)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (102862208..102871837)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene suppressor of IKBKE 1 Neighboring gene cold shock domain containing E1, RNA binding Neighboring gene adenosine monophosphate deaminase 1 Neighboring gene DENN/MADD domain containing 2C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Ras protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T-helper 1 type immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to protozoan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of skeletal muscle tissue development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of skeletal muscle tissue development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-gamma production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    GTPase NRas
    Names
    transforming protein N-Ras

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368638.1NP_001355567.1  GTPase NRas precursor

      Status: VALIDATED

      Source sequence(s)
      AC163297
    2. NM_010937.2NP_035067.2  GTPase NRas precursor

      See identical proteins and their annotated locations for NP_035067.2

      Status: VALIDATED

      Source sequence(s)
      AC163297, AK165960, BY321840, CT010359
      Consensus CDS
      CCDS38570.1
      UniProtKB/TrEMBL
      Q3TMF4, Q4FJP3, Q9D091
      Related
      ENSMUSP00000029445.6, ENSMUST00000029445.12
      Conserved Domains (1) summary
      cd04138
      Location:3164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      103058285..103067914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501123.1XP_006501186.1  GTPase NRas isoform X2

      UniProtKB/TrEMBL
      Q9D091
      Related
      ENSMUSP00000143391.1, ENSMUST00000200069.4
      Conserved Domains (1) summary
      cd04138
      Location:3164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    2. XM_006501121.3XP_006501184.1  GTPase NRas isoform X2

      See identical proteins and their annotated locations for XP_006501184.1

      UniProtKB/TrEMBL
      Q9D091
      Conserved Domains (1) summary
      cd04138
      Location:3164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    3. XM_006501120.3XP_006501183.1  GTPase NRas isoform X2

      See identical proteins and their annotated locations for XP_006501183.1

      UniProtKB/TrEMBL
      Q9D091
      Related
      ENSMUSP00000142438.1, ENSMUST00000196355.4
      Conserved Domains (1) summary
      cd04138
      Location:3164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    4. XM_006501118.1XP_006501181.1  GTPase NRas isoform X1

      See identical proteins and their annotated locations for XP_006501181.1

      Conserved Domains (2) summary
      cd04138
      Location:34195
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
      smart00173
      Location:47197
      RAS; Ras subfamily of RAS small GTPases
    5. XM_006501119.1XP_006501182.1  GTPase NRas isoform X1

      See identical proteins and their annotated locations for XP_006501182.1

      Conserved Domains (2) summary
      cd04138
      Location:34195
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
      smart00173
      Location:47197
      RAS; Ras subfamily of RAS small GTPases
    6. XM_006501122.1XP_006501185.1  GTPase NRas isoform X2

      See identical proteins and their annotated locations for XP_006501185.1

      UniProtKB/TrEMBL
      Q9D091
      Related
      ENSMUSP00000143644.1, ENSMUST00000199049.4
      Conserved Domains (1) summary
      cd04138
      Location:3164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
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