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    Mttp microsomal triglyceride transfer protein [ Mus musculus (house mouse) ]

    Gene ID: 17777, updated on 5-Mar-2019

    Summary

    Official Symbol
    Mttpprovided by MGI
    Official Full Name
    microsomal triglyceride transfer proteinprovided by MGI
    Primary source
    MGI:MGI:106926
    See related
    Ensembl:ENSMUSG00000028158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MTP; 1810043K16Rik
    Expression
    Biased expression in large intestine adult (RPKM 62.5), duodenum adult (RPKM 33.4) and 6 other tissues See more
    Orthologs

    Genomic context

    See Mttp in Genome Data Viewer
    Location:
    3 G3; 3 64.06 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (138089855..138143461, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (137752819..137806352, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene dual adaptor for phosphotyrosine and 3-phosphoinositides 1 Neighboring gene predicted gene, 19708 Neighboring gene RIKEN cDNA 1110002E22 gene Neighboring gene predicted gene 5105 Neighboring gene RIKEN cDNA 4930579F01 gene Neighboring gene tRNA methyltransferase 10A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    apolipoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    lipid transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phospholipid transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cholesterol homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    lipoprotein metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipoprotein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    lipoprotein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipoprotein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    plasma lipoprotein particle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    protein lipidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    triglyceride metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    triglyceride transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    microsomal triglyceride transfer protein large subunit
    Names
    microsomal triglyceride transfer protein B
    microsomal triglyceride transfer protein, large subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163457.2NP_001156929.1  microsomal triglyceride transfer protein large subunit isoform 1 precursor

      See identical proteins and their annotated locations for NP_001156929.1

      Status: VALIDATED

      Source sequence(s)
      AC131122, AK136278, AK146553
      Consensus CDS
      CCDS51080.1
      UniProtKB/Swiss-Prot
      O08601
      Related
      ENSMUSP00000096179.2, ENSMUST00000098580.5
      Conserved Domains (1) summary
      pfam01347
      Location:43594
      Vitellogenin_N; Lipoprotein amino terminal region
    2. NM_001355051.1NP_001341980.1  microsomal triglyceride transfer protein large subunit isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC131122
      Conserved Domains (1) summary
      cl26969
      Location:28579
      Vitellogenin_N; Lipoprotein amino terminal region
    3. NM_001355052.1NP_001341981.1  microsomal triglyceride transfer protein large subunit isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC131122
      Conserved Domains (1) summary
      cl26969
      Location:28579
      Vitellogenin_N; Lipoprotein amino terminal region
    4. NM_008642.3NP_032668.2  microsomal triglyceride transfer protein large subunit isoform 2 precursor

      See identical proteins and their annotated locations for NP_032668.2

      Status: VALIDATED

      Source sequence(s)
      AC131122, AK146553
      Consensus CDS
      CCDS38650.1
      UniProtKB/Swiss-Prot
      O08601
      Related
      ENSMUSP00000029805.8, ENSMUST00000029805.12
      Conserved Domains (1) summary
      cl26969
      Location:28579
      Vitellogenin_N; Lipoprotein amino terminal region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      138089855..138143461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501103.3XP_006501166.1  microsomal triglyceride transfer protein large subunit isoform X2

      See identical proteins and their annotated locations for XP_006501166.1

      UniProtKB/Swiss-Prot
      O08601
      Conserved Domains (1) summary
      cl26969
      Location:28579
      Vitellogenin_N; Lipoprotein amino terminal region
    2. XM_006501102.3XP_006501165.1  microsomal triglyceride transfer protein large subunit isoform X1

      See identical proteins and their annotated locations for XP_006501165.1

      UniProtKB/Swiss-Prot
      O08601
      Conserved Domains (1) summary
      pfam01347
      Location:43594
      Vitellogenin_N; Lipoprotein amino terminal region
    3. XM_017319474.1XP_017174963.1  microsomal triglyceride transfer protein large subunit isoform X2

      UniProtKB/Swiss-Prot
      O08601
      Conserved Domains (1) summary
      cl26969
      Location:28579
      Vitellogenin_N; Lipoprotein amino terminal region
    4. XM_017319475.1XP_017174964.1  microsomal triglyceride transfer protein large subunit isoform X2

      UniProtKB/Swiss-Prot
      O08601
      Conserved Domains (1) summary
      cl26969
      Location:28579
      Vitellogenin_N; Lipoprotein amino terminal region
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