Format

Send to:

Choose Destination
    • Showing Current items.

    Nudt1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 [ Mus musculus (house mouse) ]

    Gene ID: 17766, updated on 3-Feb-2019

    Summary

    Official Symbol
    Nudt1provided by MGI
    Official Full Name
    nudix (nucleoside diphosphate linked moiety X)-type motif 1provided by MGI
    Primary source
    MGI:MGI:109280
    See related
    Ensembl:ENSMUSG00000036639
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mth1
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 12.3), liver E14 (RPKM 9.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nudt1 in Genome Data Viewer
    Location:
    5; 5 G2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (140321627..140338137)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (140807876..140814089)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene MAD1 mitotic arrest deficient 1-like 1 Neighboring gene predicted gene, 30492 Neighboring gene predicted gene 16120 Neighboring gene mitochondrial rRNA methyltransferase 2 Neighboring gene sorting nexin 8 Neighboring gene predicted gene, 30550

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATP diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    GTP diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    NOT m7G(5')pppN diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    snoRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA protection ISO
    Inferred from Sequence Orthology
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    dATP catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    dGTP catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dGTP catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    purine nucleotide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    7,8-dihydro-8-oxoguanine triphosphatase
    Names
    2-hydroxy-dATP diphosphatase
    8-oxo-7,8-dihydro-2'-dGTPase
    8-oxo-dGTPase
    mutT human homolog (8-oxo-dGTPase)
    nucleoside diphosphate-linked moiety X motif 1
    nudix motif 1
    NP_032663.1
    XP_006504718.1
    XP_006504719.1
    XP_006504720.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356583.1NP_001343512.1  7,8-dihydro-8-oxoguanine triphosphatase precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      BC098239, DV649386
      Conserved Domains (1) summary
      cd03427
      Location:6140
      MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...
    2. NM_001356584.1NP_001343513.1  7,8-dihydro-8-oxoguanine triphosphatase precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AC131670
      Conserved Domains (1) summary
      cd03427
      Location:6140
      MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...
    3. NM_001356585.1NP_001343514.1  7,8-dihydro-8-oxoguanine triphosphatase precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AC131670
      Conserved Domains (1) summary
      cd03427
      Location:6140
      MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...
    4. NM_008637.2NP_032663.1  7,8-dihydro-8-oxoguanine triphosphatase precursor

      See identical proteins and their annotated locations for NP_032663.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. All four variants encode the same protein.
      Source sequence(s)
      BC098239, BQ560459, DV649386
      Consensus CDS
      CCDS19818.1
      UniProtKB/Swiss-Prot
      P53368
      Related
      ENSMUSP00000059983.5, ENSMUST00000050205.11
      Conserved Domains (1) summary
      cd03427
      Location:6140
      MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      140321627..140338137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504657.2XP_006504720.1  7,8-dihydro-8-oxoguanine triphosphatase isoform X1

      UniProtKB/Swiss-Prot
      P53368
      Conserved Domains (1) summary
      cd03427
      Location:6140
      MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...
    2. XM_006504656.2XP_006504719.1  7,8-dihydro-8-oxoguanine triphosphatase isoform X1

      UniProtKB/Swiss-Prot
      P53368
      Related
      ENSMUSP00000071778.3, ENSMUST00000071881.9
      Conserved Domains (1) summary
      cd03427
      Location:6140
      MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...
    3. XM_006504655.2XP_006504718.1  7,8-dihydro-8-oxoguanine triphosphatase isoform X1

      See identical proteins and their annotated locations for XP_006504718.1

      UniProtKB/Swiss-Prot
      P53368
      Related
      ENSMUSP00000106450.1, ENSMUST00000110826.7
      Conserved Domains (1) summary
      cd03427
      Location:6140
      MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...
    Support Center