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    Afdn afadin, adherens junction formation factor [ Mus musculus (house mouse) ]

    Gene ID: 17356, updated on 2-Apr-2019

    Summary

    Official Symbol
    Afdnprovided by MGI
    Official Full Name
    afadin, adherens junction formation factorprovided by MGI
    Primary source
    MGI:MGI:1314653
    See related
    Ensembl:ENSMUSG00000068036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AF6; Af-6; Gm314; Mllt4; Afadin; I-afadin; S-afadin; 5033403D15Rik
    Expression
    Ubiquitous expression in CNS E14 (RPKM 14.2), whole brain E14.5 (RPKM 13.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Afdn in Genome Data Viewer
    Location:
    17; 17 A1
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (13760541..13905798)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (13897548..14042801)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2700054A10 gene Neighboring gene sperm motility kinase 4A Neighboring gene predicted gene, 41530 Neighboring gene t-complex-associated testis expressed 2 Neighboring gene predicted gene 7168 Neighboring gene predicted gene, 33889

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junctions interactions, organism-specific biosystem (from REACTOME)
      Adherens junctions interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cell junction organization, organism-specific biosystem (from REACTOME)
      Cell junction organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cell-cell junction organization, organism-specific biosystem (from REACTOME)
      Cell-cell junction organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    LIM domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    Ras GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    adherens junction maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    brain morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adhesion mediated by cadherin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebral cortex development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendrite arborization ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of endothelial intestinal barrier ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    homeostasis of number of cells IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    neuroepithelial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell-cell adhesion mediated by cadherin ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mini excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to cell junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    radial glial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of oligodendrocyte progenitor proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    telencephalon development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical junction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell contact zone ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    somatodendritic compartment ISO
    Inferred from Sequence Orthology
    more info
     
    tight junction ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    afadin
    Names
    myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4
    protein Af-6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010806.1NP_034936.1  afadin

      See identical proteins and their annotated locations for NP_034936.1

      Status: VALIDATED

      Source sequence(s)
      AF172447, BI991173, BQ929757, BU611478, CB181965, CF538789, CJ165098, CK637291, CN529812, CN537179, CN538841, CO042367, CO433521
      Consensus CDS
      CCDS49955.1
      UniProtKB/Swiss-Prot
      Q9QZQ1
      Related
      ENSMUSP00000118318.1, ENSMUST00000139666.7
      Conserved Domains (7) summary
      cd01781
      Location:247346
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:417499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611932
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10081090
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam03064
      Location:15921678
      U79_P34; HSV U79 / HCMV P34
      pfam15346
      Location:15251668
      ARGLU; Arginine and glutamate-rich 1
      cl00155
      Location:20131
      UBQ; Ubiquitin-like proteins

    RNA

    1. NR_151731.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC155253, AC174800, CT030652

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      13760541..13905798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523752.2XP_006523815.1  afadin isoform X1

      Conserved Domains (7) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612940
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10161098
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15331688
      ARGLU; Arginine and glutamate-rich 1
      cl23720
      Location:15991698
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. XM_006523763.2XP_006523826.1  afadin isoform X13

      Conserved Domains (7) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612940
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10161098
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15331688
      ARGLU; Arginine and glutamate-rich 1
      cl23720
      Location:15991698
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    3. XM_006523755.2XP_006523818.1  afadin isoform X4

      Conserved Domains (7) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612940
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10161098
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam03064
      Location:16001697
      U79_P34; HSV U79 / HCMV P34
      pfam15346
      Location:15331687
      ARGLU; Arginine and glutamate-rich 1
    4. XM_006523759.2XP_006523822.1  afadin isoform X10

      Conserved Domains (7) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612940
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10161098
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam03064
      Location:16001686
      U79_P34; HSV U79 / HCMV P34
      pfam15346
      Location:15331676
      ARGLU; Arginine and glutamate-rich 1
    5. XM_006523764.2XP_006523827.1  afadin isoform X15

      Conserved Domains (7) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612940
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10161098
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam03064
      Location:16001686
      U79_P34; HSV U79 / HCMV P34
      pfam15346
      Location:15331676
      ARGLU; Arginine and glutamate-rich 1
    6. XM_006523757.2XP_006523820.1  afadin isoform X6

      Conserved Domains (7) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612933
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10091091
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15261681
      ARGLU; Arginine and glutamate-rich 1
      cl23720
      Location:15921691
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    7. XM_006523766.2XP_006523829.1  afadin isoform X14

      Related
      ENSMUSP00000114485.1, ENSMUST00000137708.7
      Conserved Domains (7) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612933
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10091091
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15261681
      ARGLU; Arginine and glutamate-rich 1
      cl23720
      Location:15921691
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    8. XM_006523760.2XP_006523823.1  afadin isoform X11

      Conserved Domains (7) summary
      cd01781
      Location:248347
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:385485
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:597925
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10011083
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15181673
      ARGLU; Arginine and glutamate-rich 1
      cl23720
      Location:15841683
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    9. XM_006523754.2XP_006523817.1  afadin isoform X3

      Conserved Domains (7) summary
      cd01781
      Location:247346
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20132
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:417499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611939
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10151097
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15321687
      ARGLU; Arginine and glutamate-rich 1
      cl23720
      Location:15981697
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    10. XM_017317275.1XP_017172764.1  afadin isoform X8

    11. XM_006523753.2XP_006523816.1  afadin isoform X2

      Conserved Domains (7) summary
      cd01781
      Location:247346
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:417499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611939
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10151097
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15321687
      ARGLU; Arginine and glutamate-rich 1
      cl23720
      Location:15981697
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    12. XM_006523765.2XP_006523828.1  afadin isoform X16

      UniProtKB/TrEMBL
      E9Q9C3
      Related
      ENSMUSP00000119153.1, ENSMUST00000137784.7
      Conserved Domains (7) summary
      cd01781
      Location:247346
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:417499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611939
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10151097
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam03064
      Location:15991685
      U79_P34; HSV U79 / HCMV P34
      pfam15346
      Location:15321675
      ARGLU; Arginine and glutamate-rich 1
      cl00155
      Location:20131
      UBQ; Ubiquitin-like proteins
    13. XM_006523758.2XP_006523821.1  afadin isoform X7

      Conserved Domains (7) summary
      cd01781
      Location:247346
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:417499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611932
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10081090
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15251680
      ARGLU; Arginine and glutamate-rich 1
      cl23720
      Location:15911690
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    14. XM_006523756.2XP_006523819.1  afadin isoform X5

      Conserved Domains (7) summary
      cd01781
      Location:246345
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:416498
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:610938
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10141096
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15311686
      ARGLU; Arginine and glutamate-rich 1
      cl23720
      Location:15971696
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    15. XM_017317276.1XP_017172765.1  afadin isoform X9

    16. XM_006523762.2XP_006523825.1  afadin isoform X12

      Conserved Domains (7) summary
      cd01781
      Location:246345
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:383483
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:595916
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:9921074
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15091664
      ARGLU; Arginine and glutamate-rich 1
      cl23720
      Location:15751674
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    17. XM_006523767.2XP_006523830.1  afadin isoform X17

      Conserved Domains (7) summary
      cd01781
      Location:246345
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd01782
      Location:20131
      AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
      cd00060
      Location:383483
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:595916
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:9921074
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam03064
      Location:15761662
      U79_P34; HSV U79 / HCMV P34
      pfam15346
      Location:15091652
      ARGLU; Arginine and glutamate-rich 1

    RNA

    1. XR_001782046.1 RNA Sequence

    2. XR_001782047.1 RNA Sequence

    3. XR_001782048.1 RNA Sequence

    4. XR_385293.2 RNA Sequence

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