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    Folr1 folate receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171049, updated on 18-Apr-2019

    Summary

    Official Symbol
    Folr1provided by RGD
    Official Full Name
    folate receptor 1provided by RGD
    Primary source
    RGD:71032
    See related
    Ensembl:ENSRNOG00000019902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fbp1
    Summary
    mouse homolog plays a role in neural tube development [RGD, Feb 2006]
    Expression
    Biased expression in Kidney (RPKM 1929.3) and Testes (RPKM 104.7) See more
    Orthologs

    Genomic context

    See Folr1 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (166934457..166945864, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (173124242..173135651, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate phosphatase-like 1 Neighboring gene putative uncharacterized protein Neighboring gene 60S ribosomal protein L12-like Neighboring gene folate receptor beta Neighboring gene anaphase promoting complex subunit 15 Neighboring gene leucine rich transmembrane and O-methyltransferase domain containing

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    drug binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    folic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    folic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    folic acid binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    folic acid receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    folic acid receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    methotrexate binding IEA
    Inferred from Electronic Annotation
    more info
     
    methotrexate binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    anterior neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    anterior neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    axon regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    axon regeneration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cardiac neural crest cell migration involved in outflow tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac neural crest cell migration involved in outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to folic acid IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to folic acid ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    folate import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    folic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    folic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    folic acid transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    heart looping IEA
    Inferred from Electronic Annotation
    more info
     
    heart looping ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neural crest cell migration involved in heart formation IEA
    Inferred from Electronic Annotation
    more info
     
    neural crest cell migration involved in heart formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    pharyngeal arch artery morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    pharyngeal arch artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to axon injury ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    anchored component of external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    anchored component of external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    anchored component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    folate receptor alpha
    Names
    folate binding protein 1
    folate receptor 1 (adult)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133527.2NP_598211.2  folate receptor alpha precursor

      Status: VALIDATED

      Source sequence(s)
      AABR07004904, FM059473, FM060472
      UniProtKB/TrEMBL
      G3V8M6
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      166934457..166945864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017588711.1XP_017444200.1  folate receptor alpha isoform X1

      UniProtKB/TrEMBL
      G3V8M6
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    2. XM_017588710.1XP_017444199.1  folate receptor alpha isoform X1

      UniProtKB/TrEMBL
      G3V8M6
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    3. XM_017588713.1XP_017444202.1  folate receptor alpha isoform X1

      UniProtKB/TrEMBL
      G3V8M6
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    4. XM_017588712.1XP_017444201.1  folate receptor alpha isoform X1

      UniProtKB/TrEMBL
      G3V8M6
      Related
      ENSRNOP00000026962.3, ENSRNOT00000026962.4
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    5. XM_006229842.3XP_006229904.1  folate receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006229904.1

      UniProtKB/TrEMBL
      G3V8M6
      Related
      ENSRNOP00000071311.1, ENSRNOT00000079675.1
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      154298870..154310077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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