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    Krt6a keratin 6A [ Mus musculus (house mouse) ]

    Gene ID: 16687, updated on 5-Feb-2019

    Summary

    Official Symbol
    Krt6aprovided by MGI
    Official Full Name
    keratin 6Aprovided by MGI
    Primary source
    MGI:MGI:1100845
    See related
    Ensembl:ENSMUSG00000058354
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K6A; MK6a; CK-6A; K6[a]; mK6[a]; Krt2-6a; Krt2-6c; 2310016L08Rik
    Expression
    Biased expression in stomach adult (RPKM 14.8), CNS E18 (RPKM 5.0) and 6 other tissues See more
    Orthologs

    Genomic context

    See Krt6a in Genome Data Viewer
    Location:
    15 F2; 15 56.97 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (101689928..101694305, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (101520359..101524736, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 5478 Neighboring gene keratin 6B Neighboring gene keratin 5 Neighboring gene keratin 71

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    antimicrobial humoral immune response mediated by antimicrobial peptide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intermediate filament organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    keratinization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    morphogenesis of an epithelium IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of growth of symbiont on or near host surface IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     
    keratin filament IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    keratin, type II cytoskeletal 6A
    Names
    60-kDa keratin
    K6-alpha
    cytokeratin-6A
    keratin complex 2, basic, gene 6a
    keratin complex 2, basic, gene 6c
    keratin-6-alpha
    mK6-alpha

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008476.3NP_032502.3  keratin, type II cytoskeletal 6A

      See identical proteins and their annotated locations for NP_032502.3

      Status: PROVISIONAL

      Source sequence(s)
      BC080820
      Consensus CDS
      CCDS27860.1
      UniProtKB/Swiss-Prot
      P50446
      Related
      ENSMUSP00000023788.6, ENSMUST00000023788.7
      Conserved Domains (3) summary
      pfam00038
      Location:151464
      Filament; Intermediate filament protein
      pfam16208
      Location:15148
      Keratin_2_head; Keratin type II head
      cl01888
      Location:377437
      DUF883; Bacterial protein of unknown function (DUF883)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      101689928..101694305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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