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    Hey2 hes-related family bHLH transcription factor with YRPW motif 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 155430, updated on 19-Mar-2019

    Summary

    Official Symbol
    Hey2provided by RGD
    Official Full Name
    hes-related family bHLH transcription factor with YRPW motif 2provided by RGD
    Primary source
    RGD:621405
    See related
    Ensembl:ENSRNOG00000013364
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Herp1
    Summary
    basic helix-loop-helix transcriptional repressor; primary target of Notch [RGD, Feb 2006]
    Expression
    Biased expression in Heart (RPKM 71.5), Lung (RPKM 40.7) and 8 other tissues See more
    Orthologs

    Genomic context

    See Hey2 in Genome Data Viewer
    Location:
    1p11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (29191170..29201257)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (30633675..30643762)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene similar to SEC24 related gene family, member C Neighboring gene similar to heterogeneous nuclear ribonucleoprotein A3 Neighboring gene transfer RNA glutamic acid (anticodon CUC) Neighboring gene nuclear receptor coactivator 7 Neighboring gene uncharacterized LOC108348877

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    • Breast cancer, organism-specific biosystem (from KEGG)
      Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Breast cancer, conserved biosystem (from KEGG)
      Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II activating transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    microsatellite binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microsatellite binding ISO
    Inferred from Sequence Orthology
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    anterior/posterior axis specification IEA
    Inferred from Electronic Annotation
    more info
     
    anterior/posterior axis specification ISO
    Inferred from Sequence Orthology
    more info
     
    arterial endothelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    arterial endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    artery development ISO
    Inferred from Sequence Orthology
    more info
     
    ascending aorta morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    ascending aorta morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    atrial septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    atrial septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    atrioventricular valve development ISO
    Inferred from Sequence Orthology
    more info
     
    blood vessel development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    blood vessel development ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac left ventricle morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac left ventricle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle hypertrophy in response to stress IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac right ventricle morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac right ventricle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac vascular smooth muscle cell development IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac vascular smooth muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac ventricle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    cochlea development IEA
    Inferred from Electronic Annotation
    more info
     
    cochlea development ISO
    Inferred from Sequence Orthology
    more info
     
    coronary vasculature morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    coronary vasculature morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    dorsal aorta morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    dorsal aorta morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    endocardial cushion to mesenchymal transition involved in heart valve formation IEA
    Inferred from Electronic Annotation
    more info
     
    endocardial cushion to mesenchymal transition involved in heart valve formation ISO
    Inferred from Sequence Orthology
    more info
     
    heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heart development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    heart trabecula formation IEA
    Inferred from Electronic Annotation
    more info
     
    heart trabecula formation ISO
    Inferred from Sequence Orthology
    more info
     
    labyrinthine layer blood vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    labyrinthine layer blood vessel development ISO
    Inferred from Sequence Orthology
    more info
     
    mesenchymal cell development IEA
    Inferred from Electronic Annotation
    more info
     
    mesenchymal cell development ISO
    Inferred from Sequence Orthology
    more info
     
    muscular septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    muscular septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of biomineral tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription initiation from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription initiation from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription regulatory region DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    outflow tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    pattern specification process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    protein-DNA complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    protein-DNA complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    pulmonary artery morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    pulmonary artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    pulmonary valve morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    pulmonary valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of inner ear auditory receptor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of inner ear auditory receptor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    tricuspid valve formation IEA
    Inferred from Electronic Annotation
    more info
     
    tricuspid valve formation ISO
    Inferred from Sequence Orthology
    more info
     
    tricuspid valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    umbilical cord morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    umbilical cord morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    vascular smooth muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    ventricular cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
     
    ventricular cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    ventricular septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    ventricular trabecula myocardium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    ventricular trabecula myocardium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Sin3 complex IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with Sin3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional repressor complex IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional repressor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hairy/enhancer-of-split related with YRPW motif protein 2
    Names
    hairy/enhancer-of-split related with YRPW motif 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130417.1NP_569101.1  hairy/enhancer-of-split related with YRPW motif protein 2

      See identical proteins and their annotated locations for NP_569101.1

      Status: VALIDATED

      Source sequence(s)
      AABR07000940
      UniProtKB/TrEMBL
      G3V7S6
      Related
      ENSRNOP00000018718.3, ENSRNOT00000018718.6
      Conserved Domains (2) summary
      smart00511
      Location:120165
      ORANGE; Orange domain
      cd00083
      Location:49105
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      29191170..29201257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      25500527..25510614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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