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    Mst1 macrophage stimulating 1 (hepatocyte growth factor-like) [ Mus musculus (house mouse) ]

    Gene ID: 15235, updated on 9-Apr-2019

    Summary

    Official Symbol
    Mst1provided by MGI
    Official Full Name
    macrophage stimulating 1 (hepatocyte growth factor-like)provided by MGI
    Primary source
    MGI:MGI:96080
    See related
    Ensembl:ENSMUSG00000032591
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hgfl; D3F15S2h; DNF15S2h; D9H3F15S2
    Expression
    Biased expression in liver adult (RPKM 91.5), liver E18 (RPKM 53.6) and 2 other tissues See more
    Orthologs

    Genomic context

    See Mst1 in Genome Data Viewer
    Location:
    9 F1; 9 59.07 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (108080405..108085027)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (107982767..107987358)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene GDP-mannose pyrophosphorylase B Neighboring gene ring finger protein 123 Neighboring gene adhesion molecule with Ig like domain 3 Neighboring gene microRNA 7088 Neighboring gene acylpeptide hydrolase Neighboring gene predicted gene, 46132 Neighboring gene bassoon

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    embryo implantation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mammary duct terminal end bud growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mammary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epithelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mammary gland epithelial cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of mammary gland epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of JAK-STAT cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cAMP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of macrophage chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of macrophage chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    vacuole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    hepatocyte growth factor-like protein
    Names
    MSP
    macrophage stimulatory protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008243.3NP_032269.3  hepatocyte growth factor-like protein precursor

      See identical proteins and their annotated locations for NP_032269.3

      Status: VALIDATED

      Source sequence(s)
      AC137678, AK134222, M74181
      Consensus CDS
      CCDS40766.1
      UniProtKB/Swiss-Prot
      P26928
      UniProtKB/TrEMBL
      Q3UZ05
      Related
      ENSMUSP00000035211.7, ENSMUST00000035211.13
      Conserved Domains (4) summary
      smart00020
      Location:488709
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:377459
      KR; Kringle domain
      cd00190
      Location:489712
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00024
      Location:2596
      PAN_1; PAN domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      108080405..108085027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511639.3XP_006511702.2  hepatocyte growth factor-like protein isoform X1

      Conserved Domains (2) summary
      smart00130
      Location:400482
      KR; Kringle domain
      pfam00024
      Location:2596
      PAN_1; PAN domain
    2. XM_011242856.2XP_011241158.1  hepatocyte growth factor-like protein isoform X2

      Conserved Domains (2) summary
      smart00020
      Location:230451
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:231454
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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