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    Kat2a K(lysine) acetyltransferase 2A [ Mus musculus (house mouse) ]

    Gene ID: 14534, updated on 12-Mar-2019

    Summary

    Official Symbol
    Kat2aprovided by MGI
    Official Full Name
    K(lysine) acetyltransferase 2Aprovided by MGI
    Primary source
    MGI:MGI:1343101
    See related
    Ensembl:ENSMUSG00000020918
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gcn5; Gcn5l2; mmGCN5; AW212720; 1110051E14Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 33.5), ovary adult (RPKM 29.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Kat2a in Genome Data Viewer
    Location:
    11 D; 11 63.53 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (100704746..100712478, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (100566062..100573768, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene zinc finger protein 385C Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 58, opposite strand Neighboring gene predicted gene, 38483 Neighboring gene DEXH (Asp-Glu-X-His) box polypeptide 58 Neighboring gene heat shock protein, alpha-crystallin-related, B9 Neighboring gene RAB5C, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    H3 histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    H3 histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase activity (H4-K12 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone succinyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptide-lysine-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    alpha-tubulin acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H3 acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H3 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H3-K14 acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H4-K12 acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    histone succinylation ISO
    Inferred from Sequence Orthology
    more info
     
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    internal peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular distribution of mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metencephalon development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    midbrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell projection organization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of histone acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of regulatory T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    somitogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    telencephalon development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Ada2/Gcn5/Ada3 transcription activator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Ada2/Gcn5/Ada3 transcription activator complex ISO
    Inferred from Sequence Orthology
    more info
     
    STAGA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    STAGA complex ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with oxoglutarate dehydrogenase complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor TFTC complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone acetyltransferase KAT2A
    Names
    GCN5 general control of amino acid synthesis-like 2
    PCAF-B/GCN5
    general control of amino acid synthesis 5-like 2
    general control of amino acid synthesis protein 5-like 2
    general control of amino acid synthesis, yeast homolog-like 2
    general control of amino acid synthesis-like 2
    histone acetyltransferase GCN5
    histone succinyltransferase KAT2A
    lysine acetyltransferase 2A
    NP_001033099.1
    NP_064388.2
    XP_017169759.1
    XP_017169760.1
    XP_017169761.1
    XP_017169762.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038010.2NP_001033099.1  histone acetyltransferase KAT2A isoform b

      See identical proteins and their annotated locations for NP_001033099.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AK155842, AL591469, AV014576
      Consensus CDS
      CCDS25432.1
      UniProtKB/TrEMBL
      Q6P3Z8
      Related
      ENSMUSP00000006973.5, ENSMUST00000006973.11
      Conserved Domains (4) summary
      cd05509
      Location:724823
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:484824
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00583
      Location:547619
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam06466
      Location:81330
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
    2. NM_020004.5NP_064388.2  histone acetyltransferase KAT2A isoform a

      See identical proteins and their annotated locations for NP_064388.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK155842, AK158079, AL591469, AV014576
      Consensus CDS
      CCDS25433.1
      UniProtKB/Swiss-Prot
      Q9JHD2
      UniProtKB/TrEMBL
      Q6P3Z8
      Related
      ENSMUSP00000099407.3, ENSMUST00000103118.3
      Conserved Domains (4) summary
      cd05509
      Location:725824
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:485825
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00583
      Location:548620
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam06466
      Location:81330
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      100704746..100712478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314271.1XP_017169760.1  histone acetyltransferase KAT2A isoform X2

    2. XM_017314270.1XP_017169759.1  histone acetyltransferase KAT2A isoform X1

    3. XM_017314273.1XP_017169762.1  histone acetyltransferase KAT2A isoform X4

    4. XM_017314272.1XP_017169761.1  histone acetyltransferase KAT2A isoform X3

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