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    Folr1 folate receptor 1 (adult) [ Mus musculus (house mouse) ]

    Gene ID: 14275, updated on 31-Jan-2019

    Summary

    Official Symbol
    Folr1provided by MGI
    Official Full Name
    folate receptor 1 (adult)provided by MGI
    Primary source
    MGI:MGI:95568
    See related
    Ensembl:ENSMUSG00000001827
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBP1; Folbp1; Folbp-1
    Expression
    Biased expression in kidney adult (RPKM 188.9), placenta adult (RPKM 82.7) and 1 other tissue See more
    Orthologs

    Genomic context

    See Folr1 in Genome Data Viewer
    Location:
    7; 7 E2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (101858331..101870788, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (109006845..109019197, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene paired-like homeobox 2a Neighboring gene inositol polyphosphate phosphatase-like 1 Neighboring gene uncharacterized LOC102639173 Neighboring gene folate receptor 2 (fetal) Neighboring gene predicted gene, 35597 Neighboring gene anaphase prompoting complex C subunit 15 Neighboring gene transmembrane O-methyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    folic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    folic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    folic acid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    folic acid receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    folic acid receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    methotrexate binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    anchored component of external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    anchored component of external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    anchored component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    brush border ISO
    Inferred from Sequence Orthology
    more info
     
    brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    folate receptor alpha
    Names
    FR-alpha
    folate-binding protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252552.1NP_001239481.1  folate receptor alpha precursor

      See identical proteins and their annotated locations for NP_001239481.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 all encode the same protein.
      Source sequence(s)
      AF096319, BC138795, CD241494, CJ079096
      Consensus CDS
      CCDS21517.1
      UniProtKB/Swiss-Prot
      P35846
      Related
      ENSMUSP00000102598.1, ENSMUST00000106985.7
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    2. NM_001252553.1NP_001239482.1  folate receptor alpha precursor

      See identical proteins and their annotated locations for NP_001239482.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two different splice sites in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
      Source sequence(s)
      AF096319, BC138781, CD241494
      Consensus CDS
      CCDS21517.1
      UniProtKB/Swiss-Prot
      P35846
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    3. NM_001252554.1NP_001239483.1  folate receptor alpha precursor

      See identical proteins and their annotated locations for NP_001239483.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
      Source sequence(s)
      AF096319, BC138781, CD241494, CF617679
      Consensus CDS
      CCDS21517.1
      UniProtKB/Swiss-Prot
      P35846
      Related
      ENSMUSP00000102596.1, ENSMUST00000106983.7
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    4. NM_008034.3NP_032060.2  folate receptor alpha precursor

      See identical proteins and their annotated locations for NP_032060.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
      Source sequence(s)
      AF096319, CD241494
      Consensus CDS
      CCDS21517.1
      UniProtKB/Swiss-Prot
      P35846
      Related
      ENSMUSP00000102599.2, ENSMUST00000106986.8
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      101858331..101870788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507360.3XP_006507423.1  folate receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006507423.1

      UniProtKB/Swiss-Prot
      P35846
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    2. XM_006507363.3XP_006507426.1  folate receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006507426.1

      UniProtKB/Swiss-Prot
      P35846
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    3. XM_006507369.3XP_006507432.1  folate receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006507432.1

      UniProtKB/Swiss-Prot
      P35846
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    4. XM_006507368.3XP_006507431.1  folate receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006507431.1

      UniProtKB/Swiss-Prot
      P35846
      Related
      ENSMUSP00000102595.1, ENSMUST00000106982.7
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    5. XM_006507370.3XP_006507433.1  folate receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006507433.1

      UniProtKB/Swiss-Prot
      P35846
      Related
      ENSMUSP00000102594.1, ENSMUST00000106981.7
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    6. XM_006507365.3XP_006507428.1  folate receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006507428.1

      UniProtKB/Swiss-Prot
      P35846
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    7. XM_006507366.2XP_006507429.1  folate receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006507429.1

      UniProtKB/Swiss-Prot
      P35846
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    8. XM_006507364.2XP_006507427.1  folate receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006507427.1

      UniProtKB/Swiss-Prot
      P35846
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    9. XM_006507361.2XP_006507424.1  folate receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006507424.1

      UniProtKB/Swiss-Prot
      P35846
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    10. XM_006507367.3XP_006507430.1  folate receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006507430.1

      UniProtKB/Swiss-Prot
      P35846
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
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