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    Fgf2 fibroblast growth factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 14173, updated on 26-Feb-2019

    Summary

    Official Symbol
    Fgf2provided by MGI
    Official Full Name
    fibroblast growth factor 2provided by MGI
    Primary source
    MGI:MGI:95516
    See related
    Ensembl:ENSMUSG00000037225
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fgfb; bFGF; Fgf-2
    Expression
    Broad expression in mammary gland adult (RPKM 4.1), ovary adult (RPKM 3.7) and 18 other tissues See more
    Orthologs

    Genomic context

    See Fgf2 in Genome Data Viewer
    Location:
    3 B; 3 18.41 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (37348477..37404893)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (37247575..37303752)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene 28S ribosomal protein S33, mitochondrial pseudogene Neighboring gene centrin 4 Neighboring gene Bardet-Biedl syndrome 12 (human) Neighboring gene fibroblast growth factor 2, opposite strand Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 6 Neighboring gene spermatogenesis associated 5 Neighboring gene predicted gene, 36412 Neighboring gene PRELI domain containing 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chemoattractant activity ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear receptor transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor-receptor interaction ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of MAPKK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    angiogenesis involved in coronary vascular morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    chondroblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    corticotropin hormone secreting cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    embryo development ending in birth or egg hatching ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    glial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    growth factor dependent regulation of skeletal muscle satellite cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    hyaluronan catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    inositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    lung development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lung development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mammary gland epithelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    organ induction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    paracrine signaling ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell fate specification ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cerebellar granule cell precursor proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endothelial cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of osteoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of vascular endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of retinal cell programmed cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    response to axon injury IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stem cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    substantia nigra development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thyroid-stimulating hormone-secreting cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    fibroblast growth factor 2
    Names
    HBGF-2
    basic fibroblast growth factor
    heparin-binding growth factor 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008006.2NP_032032.1  fibroblast growth factor 2 precursor

      See identical proteins and their annotated locations for NP_032032.1

      Status: VALIDATED

      Source sequence(s)
      AF065904, AL669927, BY730691, CJ098597
      Consensus CDS
      CCDS17320.1
      UniProtKB/Swiss-Prot
      P15655
      UniProtKB/TrEMBL
      Q541T2
      Related
      ENSMUSP00000143094.1, ENSMUST00000200585.4
      Conserved Domains (1) summary
      pfam00167
      Location:27148
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      37348477..37404893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535399.3XP_006535462.1  fibroblast growth factor 2 isoform X1

      See identical proteins and their annotated locations for XP_006535462.1

      Conserved Domains (1) summary
      pfam00167
      Location:27159
      FGF; Fibroblast growth factor

    Reference GRCm38.p4 129S1/SvImJ

    Genomic

    1. NT_039248.1 Reference GRCm38.p4 129S1/SvImJ

      Range
      245047..296117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_039247.2 Reference GRCm38.p4 NOD/MrkTac

      Range
      2773..2988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_039252.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      285936..286307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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