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    Erbb3 erb-b2 receptor tyrosine kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 13867, updated on 26-Feb-2019

    Summary

    Official Symbol
    Erbb3provided by MGI
    Official Full Name
    erb-b2 receptor tyrosine kinase 3provided by MGI
    Primary source
    MGI:MGI:95411
    See related
    Ensembl:ENSMUSG00000018166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Her3; C76256; Erbb-3; Erbb3r
    Expression
    Biased expression in colon adult (RPKM 49.8), large intestine adult (RPKM 38.8) and 13 other tissues See more
    Orthologs

    Genomic context

    See Erbb3 in Genome Data Viewer
    Location:
    10 D3; 10 77.1 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (128569368..128589501, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (128006424..128026557, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene 9176 Neighboring gene proliferation-associated 2G4 Neighboring gene microRNA 6917 Neighboring gene predicted gene 9182 Neighboring gene ribosomal protein S26

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC117742

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    neuregulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuregulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    neuregulin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuregulin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    NOT protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Schwann cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cranial nerve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocardial cushion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of calcineurin-NFAT signaling cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cardiac muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basal plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    receptor tyrosine-protein kinase erbB-3
    Names
    avian erythroblastosis oncogene B 3 receptor
    c-erbB-3
    glial growth factor receptor
    proto-oncogene-like protein c-ErbB-3
    v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
    NP_034283.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010153.2NP_034283.1  receptor tyrosine-protein kinase erbB-3 precursor

      See identical proteins and their annotated locations for NP_034283.1

      Status: VALIDATED

      Source sequence(s)
      AA119766, AC117232, BC106091
      Consensus CDS
      CCDS24283.1
      UniProtKB/Swiss-Prot
      Q61526
      Related
      ENSMUSP00000080716.6, ENSMUST00000082059.6
      Conserved Domains (8) summary
      cd12095
      Location:638674
      TM_ErbB3; Transmembrane domain of ErbB3, a Protein Tyrosine Kinase
      smart00261
      Location:548592
      FU; Furin-like repeats
      cd00064
      Location:226266
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:179329
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:353474
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:707963
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14843
      Location:499630
      GF_recep_IV; Growth factor receptor domain IV
      cl21453
      Location:699977
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      128569368..128589501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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