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    Dlg4 discs large MAGUK scaffold protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 13385, updated on 9-Apr-2019

    Summary

    Official Symbol
    Dlg4provided by MGI
    Official Full Name
    discs large MAGUK scaffold protein 4provided by MGI
    Primary source
    MGI:MGI:1277959
    See related
    Ensembl:ENSMUSG00000020886
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dlgh4; PSD95; SAP90; PSD-95; SAP90A
    Expression
    Biased expression in cortex adult (RPKM 161.9), frontal lobe adult (RPKM 143.5) and 10 other tissues See more
    Orthologs

    Genomic context

    See Dlg4 in Genome Data Viewer
    Location:
    11; 11 B3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (70018455..70045535)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69832107..69859034)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene dishevelled segment polarity protein 2 Neighboring gene acyl-Coenzyme A dehydrogenase, very long chain Neighboring gene microRNA 324 Neighboring gene asialoglycoprotein receptor 1 Neighboring gene predicted gene, 32946

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    D1 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    P2Y1 nucleotide receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    acetylcholine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-1 adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-2 adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    frizzled binding ISO
    Inferred from Sequence Orthology
    more info
     
    glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    immunoglobulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ionotropic glutamate receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ionotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    neurexin family protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    neuroligin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    structural constituent of postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    structural molecule activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    AMPA glutamate receptor clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    AMPA glutamate receptor clustering ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to potassium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dendritic spine morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    locomotory behavior NAS
    Non-traceable Author Statement
    more info
    PubMed 
    locomotory exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neurotransmitter receptor localization to postsynaptic specialization membrane EXP
    Inferred from Experiment
    more info
    PubMed 
    neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neurotransmitter receptor localization to postsynaptic specialization membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection arborization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic neurotransmitter receptor diffusion trapping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postsynaptic neurotransmitter receptor diffusion trapping ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to synapse ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    receptor clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    receptor localization to synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    receptor localization to synapse ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of NMDA receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of grooming behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of long-term neuronal synaptic plasticity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of neuronal synaptic plasticity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to cocaine NAS
    Non-traceable Author Statement
    more info
    PubMed 
    social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic vesicle maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle maturation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    vocalization behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    AMPA glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    anchored component of postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cerebellar mossy fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    excitatory synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with ionotropic glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with ionotropic glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    juxtaparanode region of axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    disks large homolog 4
    Names
    PSD-95 alpha 2b
    PSD-95 beta
    SAP-90
    discs large homolog 4
    discs, large homolog 4
    postsynaptic density protein 95
    synapse-associated protein 90

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109752.1NP_001103222.1  disks large homolog 4 isoform 2

      See identical proteins and their annotated locations for NP_001103222.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site which results in lacking of 9 nts in the CDS, as compared to variant 1. The resulting isoform 2 is shorter but has identical N- and C-termini, as compared to isoform 1.
      Source sequence(s)
      BC014807, BQ959940, CA320223
      Consensus CDS
      CCDS48829.1
      UniProtKB/Swiss-Prot
      Q62108
      Related
      ENSMUSP00000156345.1, ENSMUST00000231415.1
      Conserved Domains (7) summary
      cd12030
      Location:427492
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00072
      Location:541707
      GuKc; Guanylate kinase homologues
      smart00228
      Location:307391
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00595
      Location:62146
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:530708
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:242309
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:1061
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    2. NM_007864.3NP_031890.1  disks large homolog 4 isoform 1

      See identical proteins and their annotated locations for NP_031890.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC014807, BI738861, BQ959940, CA320223
      Consensus CDS
      CCDS36202.1
      UniProtKB/Swiss-Prot
      Q62108
      Related
      ENSMUSP00000104229.2, ENSMUST00000108588.8
      Conserved Domains (7) summary
      cd12030
      Location:430495
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00072
      Location:544710
      GuKc; Guanylate kinase homologues
      smart00228
      Location:310394
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00595
      Location:65149
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:533711
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:245312
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:1064
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      70018455..70045535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532144.2XP_006532207.1  disks large homolog 4 isoform X1

      See identical proteins and their annotated locations for XP_006532207.1

      Conserved Domains (7) summary
      cd12030
      Location:460525
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00072
      Location:574740
      GuKc; Guanylate kinase homologues
      smart00228
      Location:340424
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00595
      Location:95179
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:563741
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:275342
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:1094
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    2. XM_006532148.2XP_006532211.1  disks large homolog 4 isoform X3

      See identical proteins and their annotated locations for XP_006532211.1

      Conserved Domains (7) summary
      cd12030
      Location:408473
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00072
      Location:522688
      GuKc; Guanylate kinase homologues
      smart00228
      Location:288372
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00595
      Location:43127
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:511689
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:223290
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:1142
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    3. XM_006532150.2XP_006532213.1  disks large homolog 4 isoform X5

      See identical proteins and their annotated locations for XP_006532213.1

      Conserved Domains (7) summary
      cd12030
      Location:405470
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00072
      Location:519685
      GuKc; Guanylate kinase homologues
      smart00228
      Location:285369
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00595
      Location:40124
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:508686
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:220287
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:1139
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    4. XM_017314248.1XP_017169737.1  disks large homolog 4 isoform X6

      Related
      ENSMUSP00000018700.7, ENSMUST00000018700.13
    5. XM_006532147.3XP_006532210.2  disks large homolog 4 isoform X2

    6. XM_006532149.3XP_006532212.2  disks large homolog 4 isoform X4

    RNA

    1. XR_001779872.1 RNA Sequence

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187026.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      123090..150013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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