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    Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 13078, updated on 9-Apr-2019

    Summary

    Official Symbol
    Cyp1b1provided by MGI
    Official Full Name
    cytochrome P450, family 1, subfamily b, polypeptide 1provided by MGI
    Primary source
    MGI:MGI:88590
    See related
    Ensembl:ENSMUSG00000024087
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CP1B; CYPIB1; P4501b1
    Expression
    Biased expression in ovary adult (RPKM 41.8), spleen adult (RPKM 11.1) and 7 other tissues See more
    Orthologs

    Genomic context

    See Cyp1b1 in Genome Data Viewer
    Location:
    17; 17 E3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (79696282..79715330, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (80106293..80114381, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41623 Neighboring gene mps one binder kinase activator-like 2B pseudogene Neighboring gene regulator of microtubule dynamics 2 Neighboring gene predicted gene, 33006 Neighboring gene predicted gene, 41624 Neighboring gene predicted gene, 33055

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    DNA modification ISO
    Inferred from Sequence Orthology
    more info
     
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    arachidonic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    arachidonic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    benzene-containing compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular aromatic compound metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular aromatic compound metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular aromatic compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    collagen fibril organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT dibenzo-p-dioxin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelial cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    estrogen metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    estrogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JAK-STAT cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular endothelial growth factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retina vasculature development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retinal blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retinal metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retinal metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    retinol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retinol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    toxin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    trabecular meshwork development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cytochrome P450 1B1
    Names
    cytochrome P450, 1b1, benz[a]anthracene inducible
    cytochrome P450CMEF
    cytochrome P450EF
    NP_034124.1
    XP_006523640.1
    XP_006523642.1
    XP_011244568.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364889.1NP_001351818.1  cytochrome P450 1B1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK139368
      Conserved Domains (1) summary
      pfam00067
      Location:51472
      p450; Cytochrome P450
    2. NM_009994.2NP_034124.1  cytochrome P450 1B1 isoform 1

      See identical proteins and their annotated locations for NP_034124.1

      Status: VALIDATED

      Source sequence(s)
      AC132612, AK137461, CJ059150
      Consensus CDS
      CCDS28986.1
      UniProtKB/Swiss-Prot
      Q64429
      Related
      ENSMUSP00000024894.1, ENSMUST00000024894.1
      Conserved Domains (1) summary
      pfam00067
      Location:51518
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      79696282..79715330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523577.3XP_006523640.1  cytochrome P450 1B1 isoform X1

      Conserved Domains (1) summary
      pfam00067
      Location:51472
      p450; Cytochrome P450
    2. XM_006523579.3XP_006523642.1  cytochrome P450 1B1 isoform X2

      Conserved Domains (1) summary
      pfam00067
      Location:51472
      p450; Cytochrome P450
    3. XM_011246266.2XP_011244568.1  cytochrome P450 1B1 isoform X3

      Related
      ENSMUSP00000157049.1, ENSMUST00000234361.1
      Conserved Domains (1) summary
      pfam00067
      Location:51472
      p450; Cytochrome P450
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