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    Ackr3 atypical chemokine receptor 3 [ Mus musculus (house mouse) ]

    Gene ID: 12778, updated on 23-Apr-2019

    Summary

    Official Symbol
    Ackr3provided by MGI
    Official Full Name
    atypical chemokine receptor 3provided by MGI
    Primary source
    MGI:MGI:109562
    See related
    Ensembl:ENSMUSG00000044337
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rdc1; Cxcr7; RDC-1; CXC-R7; CXCR-7; Cmkor1; AW541270
    Expression
    Broad expression in adrenal adult (RPKM 169.3), heart adult (RPKM 116.2) and 20 other tissues See more
    Orthologs

    Genomic context

    See Ackr3 in Genome Data Viewer
    Location:
    1 D; 1 45.28 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (90203980..90215724)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (92100578..92112863)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene IQ motif containing with AAA domain Neighboring gene RIKEN cDNA 4930434B07 gene Neighboring gene predicted gene, 34930 Neighboring gene RIKEN cDNA 2700003A03 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    C-X-C chemokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    C-X-C chemokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    scavenger receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chemokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of mesenchymal stem cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    atypical chemokine receptor 3
    Names
    C-X-C chemokine receptor type 7
    G-protein coupled receptor RDC1 homolog
    chemokine (C-X-C motif) receptor 7
    chemokine orphan receptor 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271607.1NP_001258536.1  atypical chemokine receptor 3

      See identical proteins and their annotated locations for NP_001258536.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC110261, AC120878
      Consensus CDS
      CCDS15152.1
      UniProtKB/Swiss-Prot
      P56485
      Conserved Domains (1) summary
      pfam00001
      Location:62315
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. NM_007722.4NP_031748.2  atypical chemokine receptor 3

      See identical proteins and their annotated locations for NP_031748.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC110261, AK031100, BQ033958
      Consensus CDS
      CCDS15152.1
      UniProtKB/Swiss-Prot
      P56485
      Related
      ENSMUSP00000069114.4, ENSMUST00000065587.4
      Conserved Domains (1) summary
      pfam00001
      Location:62315
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      90203980..90215724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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